Recent progress in nanoscale metal-organic frameworks for drug release and cancer therapy

被引：95
作者：
He, Liangcan [1 ,2 ]
Liu, Yuan [2 ]
Lau, Joseph [2 ]
Fan, Wenpei [2 ]
Li, Qunying [1 ]
Zhang, Chao [1 ]
Huang, Pintong [1 ]
Chen, Xiaoyuan [2 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Ultrasound Med, Hangzhou 310009, Zhejiang, Peoples R China
[2] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA
来源：
NANOMEDICINE | 2019年 / 14卷 / 10期
关键词：
in situ drug encapsulation; nanoscale metal-organic frameworks; photodynamic therapy; porphyrinic metal-organic frameworks; stimuli-responsive drug release; UP-CONVERSION NANOPARTICLES; ONE-POT SYNTHESIS; MESOPOROUS SILICA NANOPARTICLES; PHOTODYNAMIC THERAPY; COORDINATION POLYMER; IMPARTING FUNCTIONALITY; IMIDAZOLATE FRAMEWORK-8; PHOTOTHERMAL THERAPY; GOLD NANOSHELLS; DELIVERY;
D O I：
10.2217/nnm-2018-0347
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nanoscale metal-organic frameworks (MOFs) have been widely used as controlled drug delivery vehicles and cancer therapy agents due to their intrinsic superior properties. Scientists have made remarkable achievements in the field of nanomedicine by using the MOFs and MOF-based multifunctional nanomaterials due to the easy synthesis into nanoscale and functionalization. In this review, we highlight the recent progress of nanoscale MOFs as drug delivery vehicles for cancer theranostics. We divide the discussion into three parts. The first and second parts focus on the drug delivery of unmodified MOF and modified MOFs, respectively, while the third part focuses on porphyrin MOFs as photosensitizers for photodynamic therapy. Finally, we conclude by identifying areas of research that we believe will propel the translation and application of MOFs.
引用
收藏
页码：1343 / 1365
页数：23
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