Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization

被引：27
|
作者：
Xu, Xiu [1 ,2 ]
Leng, Jing-Yu [3 ]
Gao, Fei [2 ]
Zhao, Zhen-Ao [2 ]
Deng, Wen-Bo [1 ]
Liang, Xiao-Huan [1 ]
Zhang, Yi-Juan [3 ]
Zhang, Zhi-Rong [3 ]
Li, Ming [3 ]
Sha, Ai-Guo [4 ]
Yang, Zeng-Ming [1 ]
机构：
[1] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China
[2] Northeast Agr Univ, Sch Life Sci, Harbin 150030, Peoples R China
[3] Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China
[4] Bailu Hosp, Reprod Med Ctr, Xiamen 361000, Peoples R China
来源：
FEBS LETTERS | 2014年 / 588卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Uterus; Implantation; Decidualization; Gpx3; Progesterone; ENDOMETRIAL STROMAL CELLS; MESSENGER-RIBONUCLEIC-ACID; IN-VITRO DECIDUALIZATION; EMBRYO IMPLANTATION; EARLY-PREGNANCY; BINDING PROTEIN-1; PROLACTIN; GENES; ADENOCARCINOMA; HYDROPEROXIDE;
D O I：
10.1016/j.febslet.2014.02.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutathione peroxidase 3 (GPX3) is an important member of antioxidant enzymes for reducing reactive oxygen species and maintaining the oxygen balance. Gpx3 mRNA is strongly expressed in decidual cells from days 5 to 8 of pregnancy. After pregnant mice are treated with GPX inhibitor for 3 days, pregnancy rate is significantly reduced. Progesterone stimulates Gpx3 expression through PR/HIF1 alpha in mouse endometrial stromal cells. In the decidua, the high level of GPX3 expression is closely associated with the reduction of hydrogen peroxide (H2O2). Based on our data, GPX3 may play a major role in reducing H2O2 during decidualization. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：1580 / 1589
页数：10
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