Human Antibody Responses to Avian Influenza A(H7N9) Virus, 2013

被引：58

作者：

Guo, Li ^{[1
,2
]}

Zhang, Xi ^{[3
]}

Ren, Lili ^{[1
,2
]}

Yu, Xuelian ^{[3
]}

Chen, Lijuan ^{[4
]}

Zhou, Hongli ^{[2
]}

Gao, Xin ^{[2
]}

Teng, Zheng ^{[3
]}

Li, Jianguo ^{[1
,2
]}

Hu, Jiayu ^{[3
]}

Wu, Chao ^{[2
]}

Xiao, Xia ^{[2
]}

Zhu, Yiyi ^{[3
]}

Wang, Quanyi ^{[4
]}

Pang, Xinghuo ^{[4
]}

Jin, Qi ^{[1
,2
]}

Wu, Fan ^{[3
]}

Wang, Jianwei ^{[1
,2
]}

机构：

[1] MOH Key Lab Syst Biol Pathogens, Beijing, Peoples R China

[2] Inst Pathogen Biol, Beijing, Peoples R China

[3] Shanghai Municipal Ctr Dis Control & Prevent, Shanghai, Peoples R China

[4] Beijing Municipal Ctr Dis Control & Prevent, Beijing, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2014年 / 20卷 / 02期

关键词：

A H7N9 VIRUS; HUMAN INFECTION; H5N1; VIRUSES; NEUTRALIZING ANTIBODY; HEMAGGLUTININ; ORIGIN; H1N1; EPIDEMIC; OUTBREAK; POULTRY;

D O I：

10.3201/eid2002.131094

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Understanding host antibody response is crucial for predicting disease severity and for vaccine development. We investigated antibody responses against influenza A(H7N9) virus in 48 serum samples from 21 patients, including paired samples from 15 patients. IgG against subtype H7 and neutralizing antibodies (NAbs) were not detected in acute-phase samples, but ELISA geometric mean titers increased in convalescent-phase samples; NAb titers were 20-80 (geometric mean titer 40). Avidity to IgG against subtype H7 was significantly lower than that against H1 and H3. IgG against H3 was boosted after infection with influenza A(H7N9) virus, and its level in acute-phase samples correlated with that against H7 in convalescent-phase samples. A correlation was also found between hemagglutinin inhibition and NAb titers and between hemagglutinin inhibition and IgG titers against H7. Because of the relatively weak protective antibody response to influenza A(H7N9), Multiple vaccinations might be needed to achieve protective immunity.

引用

页码：192 / 200

页数：9

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