IMPLICATIONS OF SEX HORMONES IN THE TREATMENT OF WOMEN WITH EPILEPSY: CATAMENIAL EPILEPSY

被引：2

作者：

Craiu, D. ^{[1
]}

机构：

[1] Alexandru Obregia Hosp Pediat Neurol, Bucharest, Romania

来源：

ACTA ENDOCRINOLOGICA-BUCHAREST | 2014年 / 10卷 / 01期

关键词：

sex hormones; epilepsy; catamenial; contraception; brain development; women; antiepileptic drugs; POLYCYSTIC-OVARY-SYNDROME; AGE-RELATED-CHANGES; ANTIEPILEPTIC DRUGS; ORAL-CONTRACEPTIVES; WHITE-MATTER; BRAIN; NEUROSTEROIDS; ADOLESCENCE; LAMOTRIGINE; CHILDHOOD;

D O I：

10.4183/aeb.2014.102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The impact of sex hormones on body development is well known and extensively studied. It is important for physicians dealing with women with epilepsy (WWE) to understand the relationship between hormones brain excitability antiepileptic medication in the attempt of finding the most appropriate care for this population. This article presents current knowledge concerning 1. Influence of hormones on neuronal excitability and epilepsy (with general proconvulsant effect of estrogens and anticonvulsant of progesterone); 2. Role of sex hormones on brain development during puberty; 3. The influence of epilepsy and antiepileptic drugs (AEDs) on hormonal constellation, fertility and reproductive endocrine disorders including polycystic ovary syndrome; 4. Catamenial epilepsy (endocrinologists and neurologists should carefully investigate menstrual and epilepsy diaries, antiepileptic treatment and contraceptive method and choose treatment with either progesterone for Cl menstrual type, or acetazolamide, benzodiazepines, antiepileptic medication for C2 and C3 types); 5. Contraception in WWE. Theoretical and practical issues are being discussed and organised into clinical practice recommendations.

引用

页码：102 / 117

页数：16

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