Surveillance of the genetic variation in incident HIV, HCV, and HBV infections in blood and plasma donors: Implications for blood safety, diagnostics, treatment, and molecular epidemiology

被引:12
|
作者
Delwart, Eric [1 ]
Kuhns, Mary C.
Busch, Michael P.
机构
[1] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
[3] Abbott Diagnost Div, Abbott Pk, IL USA
关键词
HIV; HBV; HCV; incident infections; diagnostics;
D O I
10.1002/jmv.20604
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Surveillance for molecular variants in blood donors is vital to assuring that blood screening and supplemental assays are sensitive to circulating strains of blood-borne viruses. Blood screening and diagnostic assays licensed in the United States are largely based on prototype viral strains. Documentation of divergent viral strains in the donor pool can lead to accelerated development and licensure of robust serologic and nucleic acid amplification (NAT) assays for donor screening and diagnostic applications. In addition, surveillance for viral variants among donors has implications for assessing the prevalence of drug and vaccine escape mutants and for detecting and monitoring rare variants that may be newly introduced or increasing in the United States donor population. Combined NAT and serologic screening, supplemented by novel serologic testing strategies, can be used to identify donors with incident infections, which are of particular interest with respect to blood safety and public health implications. A systematic program is proposed for the genetic characterization of viral genomes in donors with incident HIV, HCV, or HBV infections.
引用
收藏
页码:S30 / S35
页数:6
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