Synthesis and Antimicrobial Activity of Copper and Zinc Complexes based on Benzimidazole scaffold

被引:0
作者
Abdelazeem, Nagwa M. [1 ]
Sroor, Farid M. [1 ]
Abdel-Aziz, Mohamed S. [2 ]
Basyouni, Wahid M. [1 ]
机构
[1] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Giza, Egypt
[2] Natl Res Ctr, Microbial Chem Dept, Giza, Egypt
来源
EGYPTIAN JOURNAL OF CHEMISTRY | 2022年 / 65卷 / 12期
关键词
Benzimidazole; Metal complexes; Antimicrobial Agents; DERIVATIVES; METAL;
D O I
10.21608/EJCHEM.2022.152140.6592
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The fundamental goal of the present study was carried out to generate novel metal complexes based on benzimidazole (BI) as a precursor with Cu and Zn cations. Herein, Cu-BI and Zn-BI complexes were prepared and characterized via Fourier transform infrared spectroscopy (FT-IR), UV-visible, 1H NMR, and mass spectra. Moreover, antimicrobial activity of the benzimidazole, zinc, and copper complexes was evaluated using different methods as disc agar and colony forming techniques. The obtained results revealed that the Cu-BI complex could offer the best antimicrobial activity.
引用
收藏
页码:39 / 47
页数:9
相关论文
共 45 条
  • [1] Tropolone alkaloids from Colchicum kurdicum (Bornm.) Stef. (Colchicaceae) as the potent novel antileishmanial compounds; purification, structure elucidation, antileishmanial activities and molecular docking studies
    Azadbakht, Mohammad
    Davoodi, Ali
    Hosseinimehr, Seyed Jalal
    Keighobadi, Masoud
    Fakhar, Mahdi
    Valadan, Reza
    Faridnia, Roghiyeh
    Emami, Saeed
    Azadbakht, Masoud
    Bakhtiyari, Adel
    [J]. EXPERIMENTAL PARASITOLOGY, 2020, 213
  • [2] Bakhotmah D. A., 2019, POLYCYCL AROMAT COMP, P1
  • [3] The therapeutic journey of benzimidazoles: A review
    Bansal, Yogita
    Silakari, Om
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (21) : 6208 - 6236
  • [4] BAUER AW, 1966, AM J CLIN PATHOL, V45, P493
  • [5] Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria
    Dokla, Eman M. E.
    Abutaleb, Nader S.
    Milik, Sandra N.
    Li, Daoyi
    El-Baz, Karim
    Shalaby, Menna-Allah W.
    Al-Karaki, Rawan
    Nasr, Maha
    Klein, Christian D.
    Abouzid, Khaled A. M.
    Seleem, Mohamed N.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 186
  • [6] Copper complexes as therapeutic agents
    Duncan, Clare
    White, Anthony R.
    [J]. METALLOMICS, 2012, 4 (02) : 127 - 138
  • [7] Mononuclear copper(II) complexes with quinolones and nitrogen-donor heterocyclic ligands: Synthesis, characterization, biological activity and interaction with DNA
    Efthimiadou, Eleni K.
    Katsaros, Nikos
    Karaliota, Alexandra
    Psomas, George
    [J]. INORGANICA CHIMICA ACTA, 2007, 360 (15) : 4093 - 4102
  • [8] Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses
    Francesconi, Valeria
    Cichero, Elena
    Schenone, Silvia
    Naesens, Lieve
    Tonelli, Michele
    [J]. MOLECULES, 2020, 25 (07):
  • [9] Metal Complexes, an Untapped Source of Antibiotic Potential?
    Frei, Angelo
    [J]. ANTIBIOTICS-BASEL, 2020, 9 (02):
  • [10] New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity
    Galal, Shadia A.
    Hegab, Khaled H.
    Kassab, Ahmed S.
    Rodriguez, Mireya L.
    Kerwin, Sean M.
    El-Khamry, Abdel-Mo'men A.
    El Diwani, Hoda I.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (04) : 1500 - 1508