Discovery of natural mouse serum derived HIV-1 entry inhibitor(s)

被引：0
作者：
Wei, M. [1 ]
Chen, Y. [2 ]
Xi, J. [1 ]
Ru, S. [1 ]
Ji, M. [1 ]
Zhang, D. [1 ]
Fang, Q. [3 ]
Tang, B. [1 ]
机构：
[1] Bengbu Med Coll, Sch Life Sci, Inst Neurobiol, Anhui Key Lab Infect & Immun, Bengbu 233030, Peoples R China
[2] Univ Arizona, Dept Pharmacol, Coll Med, Tucson, AZ 85724 USA
[3] Bengbu Med Coll, Dept Microbiol & Parasitol, Anhui Key Lab Infect & Immun, Bengbu 233030, Peoples R China
来源：
ACTA VIROLOGICA | 2016年 / 60卷 / 04期
关键词：
HIV-1; entry; natural inhibitor; mouse serum; VIRUS; FUSION; PEPTIDE; POTENT; GP41; REPLICATION; ENFUVIRTIDE; RESISTANCE; AGONIST; CELLS;
D O I：
10.4149/av_2016_04_404
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Among rationally designed human immunodeficiency virus 1 (HIV-1) inhibitors, diverse natural factors have showed as potent anti-HIV activity in human blood. We have discovered that the boiled supernatant of healthy mouse serum could suppress HIV-1 entry, and exhibited reduced inhibitory activity after trypsin digestion. Further analysis demonstrated that only the fraction containing 10-25 K proteins could inhibit HIV-1 mediated cell-cell fusion. These results suggest that the 10-25 K protein(s) is novel natural HIV-1 entry inhibitor(s). Our findings provide important information about novel natural HIV entry inhibitors in mouse serum.
引用
收藏
页码：404 / 409
页数：6
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