The Janus-Faced Role of Aryl Hydrocarbon Receptor Signaling in the Skin: Consequences for Prevention and Treatment of Skin Disorders

被引：82

作者：

Haarmann-Stemmann, Thomas ^{[1
]}

Esser, Charlotte ^{[1
]}

Krutmann, Jean ^{[1
,2
]}

机构：

[1] IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Fac Med, Dusseldorf, Germany

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2015年 / 135卷 / 11期

关键词：

NECROSIS-FACTOR-ALPHA; CYTOCHROME-P450; 1A1; HUMAN KERATINOCYTES; STRESS-RESPONSE; CROSS-TALK; EXPRESSION; ACTIVATION; AHR; MECHANISM; CELLS;

D O I：

10.1038/jid.2015.285

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor expressed in all skin cell types, which is critically involved in the pathogenesis of a variety of skin diseases and thus represents a potential therapeutic target. Recent studies indicate that blocking AHR activation is desirable in some skin conditions, whereas the opposite, i.e., stimulation of AHR activation, is beneficial in another group of skin disorders. We here propose a model based on qualitative differences in canonical versus non-canonical AHR signaling to reconcile these seemingly contradictory observations.

引用

页码：2572 / 2576

页数：5

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