The central role of EED in the orchestration of polycomb group complexes

被引：120

作者：

Cao, Qi ^{[1
,2
,3
,4
]}

Wang, Xiaoju ^{[1
,2
]}

Zhao, Meng ^{[5
]}

Yang, Rendong ^{[5
]}

Malik, Rohit ^{[1
,2
]}

Qiao, Yuanyuan ^{[1
,2
]}

Poliakov, Anton ^{[1
,2
]}

Yocum, Anastasia K. ^{[1
]}

Li, Yong ^{[1
]}

Chen, Wei ^{[1
,6
]}

Cao, Xuhong ^{[1
,7
]}

Jiang, Xia ^{[1
,2
]}

Dahiya, Arun ^{[1
]}

Harris, Clair ^{[8
]}

Feng, Felix Y. ^{[1
,6
,9
]}

Kalantry, Sundeep ^{[8
]}

Qin, Zhaohui S. ^{[5
,10
]}

Dhanasekaran, Saravana M. ^{[1
,2
]}

Chinnaiyan, Arul M. ^{[1
,2
,7
,9
,11
]}

机构：

[1] Univ Michigan, Sch Med, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Houston Methodist Res Inst, Ctr Inflammat & Epigenet, Houston, TX 77030 USA

[4] Houston Methodist Res Inst, Ctr Canc, Houston, TX 77030 USA

[5] Emory Univ, Dept Biostat & Bioinformat, Atlanta, GA 30329 USA

[6] Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA

[9] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[10] Emory Univ, Ctr Comprehens Informat, Atlanta, GA 30329 USA

[11] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

美国国家卫生研究院;

关键词：

HISTONE METHYLTRANSFERASE ACTIVITY; H2A UBIQUITYLATION; STATISTICAL-MODEL; TARGET GENES; CPG ISLANDS; PROTEIN EED; EZH2; PRC2; METHYLATION; CANCER;

D O I：

10.1038/ncomms4127

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity. Taken together, we suggest an integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2.

引用

页数：13

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