The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells

被引：10
作者：
Molnarfi, Nicolas [1 ,2 ,3 ]
Benkhoucha, Mandia [1 ,2 ,3 ]
Juillard, Catherine [1 ,2 ]
Bjarnadottir, Kristbjoerg [1 ,2 ,3 ]
Lalive, Patrice H. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Hosp Geneva, Dept Clin Neurosci, Div Neurol, Unit Neuroimmunol & Multiple Sclerosis, CH-1211 Geneva 14, Switzerland
[2] Fac Med, Geneva, Switzerland
[3] Univ Geneva, Dept Pathol & Immunol, Fac Med, CH-1211 Geneva 4, Switzerland
[4] Univ Hosp Geneva, Dept Genet & Lab Med, Lab Med Serv, CH-1211 Geneva 14, Switzerland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 267卷 / 1-2期
基金：
瑞士国家科学基金会;
关键词：
Multiple sclerosis (MS); Hepatocyte growth factor; Monocyte-derived dendritic cells; Immune regulation; Neuroinflammation; MULTIPLE-SCLEROSIS; MONOCYTES; RECOVERY; IL-23; BETA;
D O I：
10.1016/j.jneuroim.2013.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：105 / 110
页数：6
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