Facile purification of honokiol and its antiviral and cytotoxic properties

被引:50
作者
Amblard, Franck
Delinsky, David
Arbiser, Jack L.
Schinazi, Raymond F. [1 ]
机构
[1] Emory Univ, Sch Med, Dept Pediat & Dermatol, Atlanta, GA 30322 USA
[2] Vet Affairs Med Ctr, Decatur, GA 30033 USA
关键词
D O I
10.1021/jm060268m
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A separation of honokiol 1 from the closely structurally related magnolol 2 was developed. Honokiol demonstrated weak activity against HIV-1 in human lymphocytes.
引用
收藏
页码:3426 / 3427
页数:2
相关论文
共 12 条
  • [1] Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo
    Bai, XH
    Cerimele, F
    Ushio-Fukai, M
    Waqas, M
    Campbell, PM
    Govindarajan, B
    Der, CJ
    Battle, T
    Frank, DA
    Ye, KQ
    Murad, E
    Dubiel, W
    Soff, G
    Arbiser, JL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (37) : 35501 - 35507
  • [2] Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan
    Esumi, T
    Makado, G
    Zhai, HF
    Shimizu, Y
    Mitsumoto, Y
    Fukuyama, Y
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (10) : 2621 - 2625
  • [3] Enantioselective syntheses of (S)- and (R)-8,9-dihydroxydihydromagnolol
    Gu, WX
    She, XG
    Pan, XF
    Yang, TK
    [J]. TETRAHEDRON-ASYMMETRY, 1998, 9 (08) : 1377 - 1380
  • [4] LO YC, 1994, BIOCHEM PHARMACOL, V47, P549, DOI 10.1016/0006-2952(94)90187-2
  • [5] Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice
    Nakazawa, T
    Yasuda, T
    Ohsawa, K
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2003, 55 (11) : 1583 - 1591
  • [6] ACTIVITIES OF 3'-AZIDO-3'-DEOXYTHYMIDINE NUCLEOTIDE DIMERS IN PRIMARY LYMPHOCYTES INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
    SCHINAZI, RF
    SOMMADOSSI, JP
    SAALMANN, V
    CANNON, DL
    XIE, MY
    HART, GC
    SMITH, GA
    HAHN, EF
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (06) : 1061 - 1067
  • [7] Separation procedures applicable to lignan analysis
    Slanina, J
    Glatz, Z
    [J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 812 (1-2): : 215 - 229
  • [8] Antiviral activities and cellular toxicities of modified 2′,3′-dideoxy-2′,3′-didehydrocytidine analogues
    Stuyver, LJ
    Lostia, S
    Adams, M
    Mathew, JS
    Pai, BS
    Grier, J
    Tharnish, PM
    Choi, Y
    Chong, Y
    Choo, H
    Chu, CK
    Otto, MJ
    Schinazi, RF
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (12) : 3854 - 3860
  • [9] TAKEYA T, 1986, CHEM PHARM BULL, V34, P2066
  • [10] EDRF-RELEASE AND CA++-CHANNEL BLOCKADE BY MAGNOLOL, AN ANTIPLATELET AGENT ISOLATED FROM CHINESE HERB MAGNOLIA-OFFICINALIS, IN RAT THORACIC AORTA
    TENG, CM
    YU, SM
    CHEN, CC
    HUANG, YL
    HUANG, TF
    [J]. LIFE SCIENCES, 1990, 47 (13) : 1153 - 1161