International trials in Paediatric Rheumatology: Current status

被引：1
作者：
Lovell, DJ
机构：
[1] Children's Hospital, Medical Center, University of Cincinnati, Cincinnati, OH
[2] Children's Hospital, Medical Center, Pavilion Building 2-129, Cincinnati, OH 45229
来源：
ANNALS OF MEDICINE | 1997年 / 29卷 / 02期
关键词：
juvenile chronic arthritis; juvenile rheumatoid arthritis; randomized controlled trials;
D O I：
10.3109/07853899709113705
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Current treatment of children with juvenile chronic arthritis (JCA) has been changed significantly by the results of randomized controlled trials (RCTs). However, due to low market appeal of JCA, few RCTs are being funded by drug companies and none in the more rare childhood rheumatic diseases. In addition, RCTs have several limitations when used for a chronic illness such a's JCA. To deal with this situation, the Pediatric Rheumatology International Trials Organization (PRINTO) is being organized to perform effectiveness trials in addition to efficacy trials in a variety of paediatric rheumatic illnesses.
引用
收藏
页码：165 / 167
页数：3
相关论文
共 11 条
  • [1] PENICILLAMINE AND HYDROXYCHLOROQUINE IN THE TREATMENT OF SEVERE JUVENILE RHEUMATOID-ARTHRITIS - RESULTS OF THE USA USSR DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
    BREWER, EJ
    GIANNINI, EH
    KUZMINA, N
    ALEKSEEV, L
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (20) : 1269 - 1276
  • [2] BREWER EJ, 1992, J RHEUMATOL, V19, P108
  • [3] Bulpitt K. J., 1994, Arthritis and Rheumatism, V37, pS199
  • [4] CASSIDY JT, 1990, TXB PEDIAT RHEUMATOL, P6
  • [5] FINK CW, 1995, J RHEUMATOL, V22, P1566
  • [6] Giannini Edward H., 1994, Arthritis and Rheumatism, V37, pS428
  • [7] METHOTREXATE IN RESISTANT JUVENILE RHEUMATOID-ARTHRITIS - RESULTS OF THE USA-USSR DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
    GIANNINI, EH
    BREWER, EJ
    KUZMINA, N
    SHAIKOV, A
    MAXIMOV, A
    VORONTSOV, I
    FINK, CW
    NEWMAN, AJ
    CASSIDY, JT
    ZEMEL, LS
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (16) : 1043 - 1049
  • [8] AURANOFIN IN THE TREATMENT OF JUVENILE RHEUMATOID-ARTHRITIS - RESULTS OF THE USA-USSR DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
    GIANNINI, EH
    BREWER, EJ
    KUZMINA, N
    SHAIKOV, A
    WALLIN, B
    [J]. ARTHRITIS AND RHEUMATISM, 1990, 33 (04): : 466 - 476
  • [9] GIANNINI EH, IN PRESS ARTHRITIS R
  • [10] O'Dell J., 1994, Arthritis and Rheumatism, V37, pS295
12