Natural Isotopic Abundance 13C and 15N Multidimensional Solid-State NMR Enabled by Dynamic Nuclear Polarization

被引：27

作者：

Smith, Adam N. ^{[1
]}

Marker, Katharina ^{[1
,2
]}

Hediger, Sabine ^{[1
]}

De Paepe, Gael ^{[1
]}

机构：

[1] Univ Grenoble Alpes, CEA, CNRS, IRIG,MEM, F-38000 Grenoble, France

[2] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2019年 / 10卷 / 16期

基金：

欧洲研究理事会;

关键词：

C-13-C-13 CORRELATION SPECTROSCOPY; CARBON-CARBON CONNECTIVITIES; CRYSTAL-STRUCTURE PREDICTION; MAGNETIC-RESONANCE; SIGNAL ENHANCEMENT; DIPOLAR COUPLINGS; ROTATING SOLIDS; MAS NMR; PROTEIN; SENSITIVITY;

D O I：

10.1021/acs.jpclett.8b03874

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Dynamic nuclear polarization (DNP) has made feasible solid-state NMR experiments that were previously thought impractical due to sensitivity limitations. One such class of experiments is the structural characterization of organic and biological samples at natural isotopic abundance (NA). Herein, we describe the many advantages of DNP-enabled ssNMR at NA, including the extraction of long-range distance constraints using dipolar recoupling pulse sequences without the deleterious effects of dipolar truncation. In addition to the theoretical underpinnings in the analysis of these types of experiments, numerous applications of DNP-enabled ssNMR at NA are discussed.

引用

页码：4652 / 4662

页数：21

共 97 条

[31] High-frequency dynamic nuclear polarization using biradicals: A multifrequency EPR lineshape analysis [J].

Hu, Kan-Nian ;

Song, Changsik ;

Yu, Hsiao-Hua ;

Swager, Timothy M. ;

Griffin, Robert G. .

JOURNAL OF CHEMICAL PHYSICS, 2008, 128 (05)

[32] 3D TEDOR NMR experiments for the simultaneous measurement of multiple carbon-nitrogen distances in uniformly 13C, 15N-labeled solids [J].

Jaroniec, CP ;

Filip, C ;

Griffin, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (36) :10728-10742

[33] Cryogenically cooled probes - A leap in NMR technology [J].

Kovacs, Helena ;

Moskau, Detlef ;

Spraul, Manfred .

Progress in Nuclear Magnetic Resonance Spectroscopy, 2005, 46 (2-3) :131-155

[34] A robust pulse sequence for the determination of small homonuclear dipolar couplings in magic-angle spinning NMR [J].

Kristiansen, PE ;

Carravetta, M ;

Lai, WC ;

Levitt, MH .

CHEMICAL PHYSICS LETTERS, 2004, 390 (1-3) :1-7

[35] Theory and applications of supercycled symmetry-based recoupling sequences in solid-state nuclear magnetic resonance [J].

Kristiansen, Per Eugen ;

Carravetta, Marina ;

van Beek, Jacco D. ;

Lai, Wai Cheu ;

Levitt, Malcolm H. .

JOURNAL OF CHEMICAL PHYSICS, 2006, 124 (23)

[36] Chemical ligation of the influenza M2 protein for solid-state NMR characterization of the cytoplasmic domain [J].

Kwon, Byungsu ;

Tietze, Daniel ;

White, Paul B. ;

Liao, Shu Y. ;

Hong, Mei .

PROTEIN SCIENCE, 2015, 24 (07) :1087-1099

[37] Optimizing Sample Preparation Methods for Dynamic Nuclear Polarization Solid-state NMR of Synthetic Polymers [J].

Le, Dao ;

Casano, Gilles ;

Phan, Trang N. T. ;

Ziarelli, Fabio ;

Ouari, Olivier ;

Aussenac, Fabien ;

Thureau, Pierre ;

Mollica, Giulia ;

Gigmes, Didier ;

Tordo, Paul ;

Viel, Stephane .

MACROMOLECULES, 2014, 47 (12) :3909-3916

[38] Interfacial Ca2+ environments in nanocrystalline apatites revealed by dynamic nuclear polarization enhanced 43Ca NMR spectroscopy [J].

Lee, Daniel ;

Leroy, Cesar ;

Crevant, Charlene ;

Bonhomme-Coury, Laure ;

Babonneau, Florence ;

Laurencin, Danielle ;

Bonhomme, Christian ;

De Paepe, Gael .

NATURE COMMUNICATIONS, 2017, 8

[39] Ultra-low temperature MAS-DNP [J].

Lee, Daniel ;

Bouleau, Eric ;

Saint-Bonnet, Pierre ;

Hediger, Sabine ;

De Paepe, Gael .

JOURNAL OF MAGNETIC RESONANCE, 2016, 264 :116-124

[40] Is solid-state NMR enhanced by dynamic nuclear polarization? [J].

Lee, Daniel ;

Hediger, Sabine ;

De Paepe, Gael .

SOLID STATE NUCLEAR MAGNETIC RESONANCE, 2015, 66-67 :6-20

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