Natural Isotopic Abundance 13C and 15N Multidimensional Solid-State NMR Enabled by Dynamic Nuclear Polarization

被引：27

作者：

Smith, Adam N. ^{[1
]}

Marker, Katharina ^{[1
,2
]}

Hediger, Sabine ^{[1
]}

De Paepe, Gael ^{[1
]}

机构：

[1] Univ Grenoble Alpes, CEA, CNRS, IRIG,MEM, F-38000 Grenoble, France

[2] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2019年 / 10卷 / 16期

基金：

欧洲研究理事会;

关键词：

C-13-C-13 CORRELATION SPECTROSCOPY; CARBON-CARBON CONNECTIVITIES; CRYSTAL-STRUCTURE PREDICTION; MAGNETIC-RESONANCE; SIGNAL ENHANCEMENT; DIPOLAR COUPLINGS; ROTATING SOLIDS; MAS NMR; PROTEIN; SENSITIVITY;

D O I：

10.1021/acs.jpclett.8b03874

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Dynamic nuclear polarization (DNP) has made feasible solid-state NMR experiments that were previously thought impractical due to sensitivity limitations. One such class of experiments is the structural characterization of organic and biological samples at natural isotopic abundance (NA). Herein, we describe the many advantages of DNP-enabled ssNMR at NA, including the extraction of long-range distance constraints using dipolar recoupling pulse sequences without the deleterious effects of dipolar truncation. In addition to the theoretical underpinnings in the analysis of these types of experiments, numerous applications of DNP-enabled ssNMR at NA are discussed.

引用

页码：4652 / 4662

页数：21

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