Dueling activities of AIF in cell death versus survival: DNA binding and redox activity

被引：151

作者：

Lipton, SA ^{[1
]}

Bossy-Wetzel, E ^{[1
]}

机构：

[1] Burnham Inst, Ctr Neurosci & Aging, La Jolla, CA 92037 USA

来源：

CELL | 2002年 / 111卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(02)01046-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.

引用

页码：147 / 150

页数：4

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