Aldosterone antagonism in heart failure: improvement of cardiac remodelling, endothelial dysfunction and platelet activation

被引:13
作者
Bauersachs, J [1 ]
机构
[1] Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany
关键词
D O I
10.1111/j.1365-2362.2004.01400.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:649 / 652
页数:4
相关论文
共 27 条
[1]   Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure [J].
Anderson, RA ;
Ellis, GR ;
Chirkov, YY ;
Holmes, AS ;
Payne, N ;
Blackman, DJ ;
Jackson, SK ;
Lewis, MJ ;
Horowitz, JD ;
Frenneaux, MP .
EUROPEAN JOURNAL OF HEART FAILURE, 2004, 6 (01) :47-54
[2]   EFFECTS OF ADDING SPIRONOLACTONE TO AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR IN CHRONIC CONGESTIVE-HEART-FAILURE SECONDARY TO CORONARY-ARTERY DISEASE [J].
BARR, CS ;
LANG, CC ;
HANSON, J ;
ARNOTT, M ;
KENNEDY, N ;
STRUTHERS, AD .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 76 (17) :1259-1265
[3]  
Bauersachs J, 2003, Minerva Cardioangiol, V51, P155
[4]   Addition of spironolactone to angiotensin-converting enzyme inhibition in heart failure improves endothelial vasomotor dysfunction - Role of vascular superoxide anion formation and endothelial nitric oxide synthase expression [J].
Bauersachs, J ;
Heck, M ;
Fraccarollo, D ;
Hildemann, SK ;
Ertl, G ;
Wehling, M ;
Christ, M .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (02) :351-358
[5]   Striking increase of natriuresis by low-dose spironolactone in congestive heart failure only in combination with ACE inhibition - Mechanistic evidence to support RALES [J].
Bauersachs, J ;
Fraccarollo, D ;
Ertl, G ;
Gretz, N ;
Wehling, M ;
Christ, M .
CIRCULATION, 2000, 102 (19) :2325-2328
[6]   Effect of Perindopril on platelet nitric oxide resistance in patients with chronic neart failure secondary to ischemic left ventricular dysfunction [J].
Chirkov, YY ;
Holmes, AS ;
Martelli, JD ;
Horowitz, JD .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (11) :1438-1440
[7]   Effect of a selective aldosterone receptor antagonist in myocardial infarction [J].
Delyani, JA ;
Robinson, EL ;
Rudolph, AE .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (02) :H647-H654
[8]   Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure [J].
Farquharson, CAJ ;
Struthers, AD .
CIRCULATION, 2000, 101 (06) :594-597
[9]   Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction [J].
Fraccarollo, D ;
Galuppo, P ;
Hildemann, S ;
Christ, M ;
Ertl, G ;
Bauersachs, J .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (09) :1666-1673
[10]   Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure [J].
Francis, J ;
Weiss, RM ;
Wei, SG ;
Johnson, AK ;
Beltz, TG ;
Zimmerman, K ;
Felder, RB .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (05) :H2241-H2251