Complexities in the genetic dissection of quantitative trait loci

被引:34
作者
Darvasi, A [1 ]
Pisanté-Shalom, A [1 ]
机构
[1] Hebrew Univ Jerusalem, Inst Life Sci, IL-91904 Jerusalem, Israel
关键词
D O I
10.1016/S0168-9525(02)02767-1
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The analysis of complex traits, including those involved in many common diseases, has encountered significant difficulties, and, despite major efforts during the past decade, has had little success. Current advances in genomics, however, promise to change this. Recently, Steinmetz et al. used a new technique to produce the first complete quantitative trait locus (QTL) analysis of a complex trait from phenotype to gene to be published entirely in a single report. This marks a significant advance over previous QTL analyses, which took several years. The work exemplifies some of the complexities of QTL mapping and demonstrates a novel method to resolve the underlying genetic architecture of QTLs in yeast. Here we discuss this work in the general context of genetic dissection of complex traits and QTLs.
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收藏
页码:489 / 491
页数:3
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