Little Necessity of Acid Inhibition against Proton Pump Inhibitor Rebound Effects and Prior Helicobacter pylori Eradication Therapy in Gastric Ulcer Patients: A Randomized Prospective Study
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Wada, Yoshihiro
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Wada, Yoshihiro
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Ito, Masanori
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Ito, Masanori
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Takata, Shunsuke
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Takata, Shunsuke
[1
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Kitamura, Shosuke
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Kitamura, Shosuke
[1
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Takamura, Akemi
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Takamura, Akemi
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Tatsugami, Masana
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Tatsugami, Masana
[1
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Imagawa, Shinobu
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Imagawa, Shinobu
[1
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Matsumoto, Yoshiaki
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Matsumoto, Yoshiaki
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Tanaka, Shinji
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Hiroshima Univ Hosp, Dept Endoscopy, Hiroshima, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Tanaka, Shinji
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Yoshihara, Masaharu
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Hiroshima Univ, Hlth Serv Ctr, Higashihiroshima, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Yoshihara, Masaharu
[3
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Chayama, Kazuaki
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Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, JapanHiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
Chayama, Kazuaki
[1
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机构:
[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan
[2] Hiroshima Univ Hosp, Dept Endoscopy, Hiroshima, Japan
[3] Hiroshima Univ, Hlth Serv Ctr, Higashihiroshima, Japan
Background/Aims: Helicobacter pylori (H. pylori) eradication therapy increases acid secretion and promotes the development of gastroesophageal reflux disease (GERD) and reflux esophagitis (RE). Rebound acid hypersecretion develops after the use of proton pump inhibitors (PPI). We examined the clinical necessity of acid inhibitors to prevent GERD or RE caused by PPI rebound phenomenon and prior H. pylori eradication therapy. Methodology: We enrolled 39 patients who underwent successful H. pylori eradication therapy prior to endoscopic mucosal resection of gastric cancer. After 8-week rabeprazole treatment for iatrogenic ulcer, they were randomly divided into two groups (who took nizatidine (group N) and sofalcone (group S)), and took each for 16 weeks, we compared RE/GERD symptoms with the baseline by endoscopy and QUEST score. Results: All patients had corpus atrophy in which there was no difference between the two groups. Only 1 patient in group S (5.9%) developed symptomatic GERD, and 1 patient in group N (4.5%) developed RE. Conclusions: In severe atrophic gastritis patients, there is little clinical necessity of acid inhibitors to prevent GERD/RE caused by PPI rebound and prior H. pylori eradication therapy.