Supramolecular Metal-Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients

被引：53

作者：

Rahim, Md Arifur ^{[1
,2
]}

Hata, Yuuki ^{[1
,2
,3
]}

Bjornmalm, Mattias ^{[1
,2
]}

Ju, Yi ^{[1
,2
]}

Caruso, Frank ^{[1
,2
]}

机构：

[1] Univ Melbourne, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Dept Chem Engn, Parkville, Vic 3010, Australia

[3] Tokyo Inst Technol, Dept Chem Sci & Engn, Sch Mat & Chem Technol, Meguro Ku, 2-12-1-H121 Ookayama, Tokyo 1528550, Japan

来源：

SMALL | 2018年 / 14卷 / 26期

基金：

澳大利亚研究理事会;

关键词：

active pharmaceutical ingredients; composites; crystallization; morphology control; supramolecular gels; SOLUBILITY; HYDROGELS; GELATORS; CAFFEINE;

D O I：

10.1002/smll.201801202

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of supramolecular gel media for the crystallization of active pharmaceutical ingredients (APIs) is of interest for controlling crystal size, morphology, and polymorphism, as these features determine the performance of pharmaceutical formulations. In contrast to supramolecular systems prepared from synthetic gelators, herein, supramolecular metallogels based on a natural polyphenol (tannic acid) are used for the crystallization of APIs. The gel-grown API crystals exhibit considerable differences in size, morphology, and polymorphism when compared with those formed in solutions. These physical features can also be tailored by varying the gel composition and additives, suggesting an influence of the gel medium on the crystallization outcomes. Furthermore, these gel-API crystal composites can be used for sustained drug release, indicating their potential as drug delivery systems. The facile preparation of these supramolecular gels and the use of naturally abundant components in their synthesis provide a generic platform for studying gel-mediated crystallization of diverse APIs.

引用

页数：6

共 23 条

[1] Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates [J].