Etidronic Acid: a New and Efficient Catalyst for the Synthesis of Novel 5-Nitro-3,4-Dihydropyrimidin-2(1H)-Ones

被引：21

作者：

Savant, Mahesh M. ^{[1
]}

Pansuriya, Akshay M. ^{[1
]}

Bhuva, Chirag V. ^{[1
]}

Kapuriya, Naval P. ^{[1
]}

Naliapara, Yogesh T. ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Chem Res Lab, Rajkot 360005, Gujarat, India

来源：

CATALYSIS LETTERS | 2009年 / 132卷 / 1-2期

关键词：

Etidronic acid; Homogenous catalyst; Cyclocondensation; Nitro-dihydropyrimidine; Multicomponent; ONE-POT SYNTHESIS; IMPROVED PROTOCOL; DIHYDROPYRIMIDINONES; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CHLORIDE;

D O I：

10.1007/s10562-009-0112-y

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A simple, convenient and efficient one-pot cyclocondensation reaction of 1-(2-hydroxyphenyl)-2-nitroethanone, arylaldehydes and urea using etidronic acid to furnish nitro dihydropyrimidine derivatives is described. A new and efficient protocol is developed as a homogenous catalyst for the synthesis of dihydropyrimidines using substituted omega-nitro acetophenone. Various bisphosphonic acids were examined to synthesized pyrimidines via multicomponent cyclocondensation reaction. This methodology has the advantage of excellent yields with short reaction time.

引用

页码：281 / 284

页数：4

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