Identification of a protective allele against Alzheimer disease in the APOE gene promoter

被引：12

作者：

Beyer, K

Lao, JI

Gómez, M

Riutort, N

Latorre, P

Mate, JL

Ariza, A

机构：

[1] Autonomous Univ Barcelona, Hosp Germans Trias & Pujol, Dept Pathol, Badalona 08916, Spain

[2] Autonomous Univ Barcelona, Hosp Germans Trias & Pujol, Dept Biochem, Badalona 08916, Spain

[3] Autonomous Univ Barcelona, Hosp Germans Trias & Pujol, Dept Neurol, Badalona 08916, Spain

[4] Dept Mol & Med Genet, Lab Anal Clin Dr Echevarne, Barcelona, Spain

来源：

NEUROREPORT | 2002年 / 13卷 / 11期

关键词：

Alzheimer disease; apolipoprotein E; APOE promoter region polymorphisms; protective allele;

D O I：

10.1097/00001756-200208070-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer disease (AD) risk is significantly influenced by the APOE2 and APOE4 alleles. In turn, the -491AT and THI/E47 cs polymorphisms alter APOE gene expression levels. To determine whether these two alleles exert any significant effect on AD development we have analysed the genotypes of the APOE promoter -491AT and Th1/E47 cs polymorphisms in 163 AD patients and 155 controls divided into three age at onset/age dependent subgroups. Our study has detected a Th1/E47cs-Tallele accumulation in healthy individuals over 75 years of age, which suggests it plays a protective role against AD. The Th1/E47cs-Tallele may provide greater protection against AD than APOE2, although this awaits proof of Th1/E47cs-T allele overrepresentation in healthy individuals of other populations.

引用

页码：1403 / 1405

页数：3

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