Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Liriope spicata Var. Prolifera in C57BL/6J Mice with High-Fat Diet-Induced Hyperlipidemia

被引：13
作者：
Liu, Yi-Hui [1 ,2 ]
Xiang, Zhi-Nan [2 ]
Chen, Chen [1 ]
Wan, Luo-Sheng [2 ]
Chen, Jia-Chun [2 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Pharm, Tongji Med Coll, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Dept Pharm, Tongji Med Sch, Wuhan 430030, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2020年 / 2020卷
关键词：
BILE-ACID SYNTHESIS; OXIDATIVE STRESS; CRUDE POLYSACCHARIDES; WATER EXTRACT; ATHEROSCLEROSIS; CHOLESTEROL; METABOLISM; MECHANISMS; RECEPTORS; DISEASE;
D O I：
10.1155/2020/8013189
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
In this study, C57BL/6J mice with high-fat diet- (HFD-) induced hyperlipidemia were treated with total Liriope spicata var. prolifera polysaccharides (TLSP: 200, 400, and 800 mg/kg body weight), simvastatin (3 mg/kg body weight), or saline for 8 weeks, respectively. The results showed that TLSP had strong lipid-lowering and hepatoprotective effects on C57BL/6J mice with HFD-induced hyperlipidemia. TLSP administration significantly reduced serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels and downregulated the expressions of peroxisome proliferator-activated receptor (PPAR)gamma and fatty acid synthase (FAS) in the adipose and liver tissues of the mice. TLSP exerted hypolipidemic and hepatoprotective effects by activating lipid/bile acid metabolism via the FXH-SHP/CYP7A1 and SEBP-1c/FAC/ACC signaling pathways. Thus, TLPS is a promising natural polymer with hepatoprotective and hypolipidemic properties.
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页数：11
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