Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Liriope spicata Var. Prolifera in C57BL/6J Mice with High-Fat Diet-Induced Hyperlipidemia

被引：13

作者：

Liu, Yi-Hui ^{[1
,2
]}

Xiang, Zhi-Nan ^{[2
]}

Chen, Chen ^{[1
]}

Wan, Luo-Sheng ^{[2
]}

Chen, Jia-Chun ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Pharm, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Dept Pharm, Tongji Med Sch, Wuhan 430030, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2020年 / 2020卷

关键词：

BILE-ACID SYNTHESIS; OXIDATIVE STRESS; CRUDE POLYSACCHARIDES; WATER EXTRACT; ATHEROSCLEROSIS; CHOLESTEROL; METABOLISM; MECHANISMS; RECEPTORS; DISEASE;

D O I：

10.1155/2020/8013189

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In this study, C57BL/6J mice with high-fat diet- (HFD-) induced hyperlipidemia were treated with total Liriope spicata var. prolifera polysaccharides (TLSP: 200, 400, and 800 mg/kg body weight), simvastatin (3 mg/kg body weight), or saline for 8 weeks, respectively. The results showed that TLSP had strong lipid-lowering and hepatoprotective effects on C57BL/6J mice with HFD-induced hyperlipidemia. TLSP administration significantly reduced serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels and downregulated the expressions of peroxisome proliferator-activated receptor (PPAR)gamma and fatty acid synthase (FAS) in the adipose and liver tissues of the mice. TLSP exerted hypolipidemic and hepatoprotective effects by activating lipid/bile acid metabolism via the FXH-SHP/CYP7A1 and SEBP-1c/FAC/ACC signaling pathways. Thus, TLPS is a promising natural polymer with hepatoprotective and hypolipidemic properties.

引用

页数：11

共 54 条

[1]

Ahima RS, 2008, FRONT HORM RES, V36, P182, DOI 10.1159/000115365

[2]

ALLAIN CC, 1974, CLIN CHEM, V20, P470

[3] Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice [J].

Bai, Xue ;

Chen, Xianghong ;

Liu, Yihui ;

Tian, Luanyuan ;

Zhou, Qun ;

Liu, Shenghong ;

Fang, Jinbo ;

Chen, Jiachun .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 125 (03) :482-486

[4] Mechanisms of Plaque Formation and Rupture [J].

Bentzon, Jacob Fog ;

Otsuka, Fumiyuki ;

Virmani, Renu ;

Falk, Erling .

CIRCULATION RESEARCH, 2014, 114 (12) :1852-1866

[5]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[6] Association of LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins A Meta-analysis [J].

Boekholdt, S. Matthijs ;

Arsenault, Benoit J. ;

Mora, Samia ;

Pedersen, Terje R. ;

LaRosa, John C. ;

Nestel, Paul J. ;

Simes, R. John ;

Durrington, Paul ;

Hitman, Graham A. ;

Welch, K. M. A. ;

DeMicco, David A. ;

Zwinderman, Aeilko H. ;

Clearfield, Michael B. ;

Downs, John R. ;

Tonkin, Andrew M. ;

Colhoun, Helen M. ;

Gotto, Antonio M., Jr. ;

Ridker, Paul M. ;

Kastelein, John J. P. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (12) :1302-1309

[7]

BUCOLO G, 1973, CLIN CHEM, V19, P476

[8] High-fat diets:: Modeling the metabolic disorders of human obesity in rodents [J].

Buettner, Roland ;

Schoelmerich, Juergen ;

Bollheimer, L. Cornelius .

OBESITY, 2007, 15 (04) :798-808

[9] Hypoglycemic Polysaccharides from the Tuberous Root of Liriope spicata [J].

Chen, Xianghong ;

Liu, Yihui ;

Bai, Xue ;

Wen, Li ;

Fang, Jinbo ;

Ye, Mao ;

Chen, Jiachun .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (11) :1988-1992

[10] Anti-diabetic effects of water extract and crude polysaccharides from tuberous root of Liriope spicata var. prolifera in mice [J].

Chen, Xianghong ;

Bai, Xue ;

Liu, Yihui ;

Tian, Luanyuan ;

Zhou, Jianqiu ;

Zhou, Qun ;

Fang, Jinbo ;

Chen, Jiachun .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 122 (02) :205-209

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