A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans

被引:15
作者
Rasmussen, Jerod M. [1 ,2 ,3 ]
Kruggel, Frithjof [3 ]
Gilmore, John H. [4 ,5 ]
Styner, Martin [4 ,5 ]
Entringer, Sonja [1 ,7 ]
Consing, Kirsten N. Z. [4 ,5 ]
Potkin, Steven G. [6 ]
Wadhwa, Pathik D. [1 ,2 ,6 ]
Buss, Claudia [1 ,2 ,7 ]
机构
[1] Univ Calif Irvine, Dev Hlth & Dis Res Program, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA
[4] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA
[5] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC USA
[6] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA
[7] Charite Univ Med Berlin, Inst Med Psychol, Luisenstr 57, D-10117 Berlin, Germany
关键词
DTI; Myelination; Non-linear; Ontology; Birth; Age; Postnatal; Gestational; NERVOUS-SYSTEM; MYELINATION; MICROSTRUCTURE; PROGRESSION; PATTERNS; BIRTH; AGE;
D O I
10.1016/j.ijdevneu.2016.12.004
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human birth presents an abrupt transition from intrauterine to extrauterine life. Here we introduce a novel Maturation Index (MI) that considers the relative importance of gestational age at birth and postnatal age at scan in a General Linear Model. The MI is then applied to Diffusion Tensor Imaging (DTI) in newborns for characterizing typical white matter development in neonates. DTI was performed cross-sectionally in 47 neonates (gestational age at birth = 39.1 +/- 11.6 weeks [GA], postnatal age at scan= 25.5 +/- 112.2 days [SA]). Radial diffusivity (RD), axial diffusivity (AD) and fractional anisotropy (FA) along 27 white matter fiber tracts were considered. The MI was used to characterize inflection in maturation at the time of birth using GLM estimated rates of change before and after birth. It is proposed that the sign (positive versus negative) of MI reflects the period of greatest maturation rate. Two general patterns emerged from the MI analysis. First, RD and AD (but not FA) had positive MI on average across the whole brain (average MIAD = 0.31 +/- 0.42, average MIRD = 0.22 +/- 10.34). Second, significant regions of negative MI in RD and FA (but not AD) were observed in the inferior corticospinal regions, areas known to myelinate early. Observations using the proposed method are consistent with proposed models of the white matter maturation process in which pre-myelination is described by changes in AD and RD due to oligodendrocyte proliferation while true myelination is characterized by changes in RD and FA due to myelin formation. (C) 2016 ISDN. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:42 / 51
页数:10
相关论文
共 37 条
  • [1] Back SA, 2001, J NEUROSCI, V21, P1302
  • [2] Development of cortical microstructure in the preterm human brain
    Ball, Gareth
    Srinivasan, Latha
    Aljabar, Paul
    Counsell, Serena J.
    Durighel, Giuliana
    Hajnal, Joseph V.
    Rutherford, Mary A.
    Edwards, A. David
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (23) : 9541 - 9546
  • [3] Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination
    Barateiro, Andreia
    Fernandes, Adelaide
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2014, 1843 (09): : 1917 - 1929
  • [4] The basis of anisotropic water diffusion in the nervous system - a technical review
    Beaulieu, C
    [J]. NMR IN BIOMEDICINE, 2002, 15 (7-8) : 435 - 455
  • [5] Axonal signals in central nervous system myelination, demyelination and remyelination
    Coman, L
    Barbin, G
    Charles, P
    Zalc, B
    Lubetzki, C
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 233 (1-2) : 67 - 71
  • [6] Modeling healthy male white matter and myelin development: 3 through 60 months of age
    Dean, Douglas C., III
    O'Muircheartaigh, Jonathan
    Dirks, Holly
    Waskiewicz, Nicole
    Lehman, Katie
    Walker, Lindsay
    Han, Michelle
    Deoni, Sean C. L.
    [J]. NEUROIMAGE, 2014, 84 : 742 - 752
  • [7] Mapping Infant Brain Myelination with Magnetic Resonance Imaging
    Deoni, Sean C. L.
    Mercure, Evelyne
    Blasi, Anna
    Gasston, David
    Thomson, Alex
    Johnson, Mark
    Williams, Steven C. R.
    Murphy, Declan G. M.
    [J]. JOURNAL OF NEUROSCIENCE, 2011, 31 (02) : 784 - 791
  • [8] DIETRICH RB, 1988, AM J NEURORADIOL, V9, P69
  • [9] THE EARLY DEVELOPMENT OF BRAIN WHITE MATTER: A REVIEW OF IMAGING STUDIES IN FETUSES, NEWBORNS AND INFANTS
    Dubois, J.
    Dehaene-Lambertz, G.
    Kulikova, S.
    Poupon, C.
    Hueppi, P. S.
    Hertz-Pannier, L.
    [J]. NEUROSCIENCE, 2014, 276 : 48 - 71
  • [10] Structural Asymmetries in the Infant Language and Sensori-Motor Networks
    Dubois, J.
    Hertz-Pannier, L.
    Cachia, A.
    Mangin, J. F.
    Le Bihan, D.
    Dehaene-Lambertz, G.
    [J]. CEREBRAL CORTEX, 2009, 19 (02) : 414 - 423