Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels

被引:40
作者
Berdugo, Cristina [1 ,2 ]
Nalluri, Siva Krishna Mohan [1 ]
Javid, Nadeem [1 ]
Escuder, Beatriu [2 ]
Miravet, Juan F. [2 ]
Ulijn, Rein V. [1 ,3 ,4 ]
机构
[1] Univ Strathclyde, WestCHEM Dept Pure & Appl Chem, Glasgow G1 IXL, Lanark, Scotland
[2] Univ Jaume 1, Dept Quim Inorgan & Organ, Castellon de La Plana 12071, Spain
[3] CUNY, Adv Sci Res Ctr, New York, NY 10031 USA
[4] CUNY Hunter Coll, New York, NY 10031 USA
基金
欧洲研究理事会;
关键词
charge transfer interactions; hydrogels; dynamic combinatorial libraries; peptide derivatives; self-assembly; thermolysin; supramolecular electronics; DONOR-ACCEPTOR; SUPRAMOLECULAR ASSEMBLIES; COMBINATORIAL CHEMISTRY; NAPHTHALENE DIIMIDES; GELATION; SEMICONDUCTOR; DESIGN; DRIVEN; ENERGY; TOOL;
D O I
10.1021/acsami.5b08968
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Coupling of peptide self-assembly to dynamic sequence exchange provides a useful approach for the discovery of self-assembling materials. In here, we demonstrate the discovery and optimization of aqueous, gel-phase nanostructures based on dynamically exchanging peptide sequences that self-select to maximize charge transfer of n-type semiconducting naphthalenediimide (NDI)-dipeptide bioconjugates with various ?-electron-rich donors (dialkoxy/hydroxy/amino-naphthalene or pyrene derivatives). These gel-phase peptide libraries are characterized by spectroscopy (UV-vis and fluorescence), microscopy (TEM), HPLC, and oscillatory rheology and it is found that, of the various peptide sequences explored (tyrosine Y-NDI with tyrosine Y, phenylalanine F, leucine L, valine V, alanine A or glycine G-NH2), the optimum sequence is tyrosine-phenylalanine in each case; however, both its absolute and relative yield amplification is dictated by the properties of the donor component, indicating cooperativity of peptide sequence and donor/acceptor pairs in assembly. The methodology provides an in situ discovery tool for nanostructures that enable dynamic interfacing of supramolecular electronics with aqueous (biological) systems.
引用
收藏
页码:25946 / 25954
页数:9
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