8-Chloro-1-methyl-6-phenyl-4H-1,2,4-triazolo[4,3-a][1,4]benzodiazepine dihydrate

被引：4

作者：

Vega, DR ^{[1
]}

Baggio, R

Russi, S

机构：

[1] Comis Nacl Energia Atom, Dept Fis, RA-1429 Buenos Aires, DF, Argentina

[2] Univ Republ, Fac Quim, Lab Cristalog, Montevideo, Uruguay

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1999年 / 55卷

关键词：

D O I：

10.1107/S0108270199010446

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alprazolam dihydrate (C17H13ClN4. 2H(2)O) crystallizes in space group P1 with Z = 4. The structure of the triazolobenzodiazepine moiety is quite similar in the four independent molecules and shows only very slight differences from those in related compounds reported in the literature. The diazepine ring displays an almost perfect boat conformation.

引用

页码：2094 / 2096

页数：3

共 17 条

[1]

Allen F.H., 1993, CHEM AUTOMAT NEWS, V8, P31

[2] 1,4-BENZODIAZEPINES AS LIGANDS - SYNTHESIS, CHARACTERIZATION AND CRYSTAL AND MOLECULAR-STRUCTURE OF BIS(8-CHLORO-6-(ORTHO-CHLOROPHENYL)-1-METHYL-4H-S-TRIAZOLO[4,3-A]1,4-BENZODIAZEPINE (TRIAZOLAM)) CADMIUM(II) DICHLORIDE [J].

BENEDETTI, A ;

FABRETTI, AC ;

PRETI, C .

JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, 1989, 19 (04) :651-660

[3] GENERAL DEFINITION OF RING PUCKERING COORDINATES [J].

CREMER, D ;

POPLE, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1354-1358

[4] ALPRAZOLAM - A REVIEW OF ITS PHARMACODYNAMIC PROPERTIES AND EFFICACY IN THE TREATMENT OF ANXIETY AND DEPRESSION [J].

DAWSON, GW ;

JUE, SG ;

BROGDEN, RN .

DRUGS, 1984, 27 (02) :132-147

[5] ON ENANTIOMORPH-POLARITY ESTIMATION [J].

FLACK, HD .

ACTA CRYSTALLOGRAPHICA SECTION A, 1983, 39 (NOV) :876-881

[6]

HESTER JB, 1971, TETRAHEDRON LETT, P1609

[7] MOLECULAR-STRUCTURES OF 8-CHLORO-6-PHENYL-4H-S-TRIAZOLO[4,3-A][1,4]BENZODIAZEPINE, 2-ACETOXYAMINO-4-ACETYL-8-CHLORO-3,4-DIHYDRO-6-PHENYL-1,4,5-BENZOTRIAZOCINE AND 8-CHLORO-4,11-DIACETYL-4,11-DIHYDRO-2-METHYL-6-PHENYLOXAZOLO[4,5-B]-[1,4,5]BENZOTRIAZOCINE - FORMATION OF AN 8-MEMBERED RING FROM A QUINAZOLINE DERIVATIVE ON TREATMENT WITH HYDRAZINE EVIDENCED BY X-RAY ANALYSISE [J].

KAMIYA, K ;

WADA, Y ;

NISHIKAWA, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1973, 21 (07) :1520-1529

[8] STRUCTURES OF 2 PSYCHOACTIVE 1,4-BENZODIAZEPINES [J].

KEMMISH, HJ ;

HAMOR, TA .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1989, 45 :475-478

[9] STRUCTURE OF AN ANALOG OF THE TRIAZOLOBENZODIAZEPINE ALPRAZOLAM [J].

KEMMISH, HJ ;

HAMOR, TA .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1988, 44 :1823-1825

[10]

LAIHANEN N, 1994, STP PHARMA SCI, V4, P381

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