The Role of GW182 Proteins in miRNA-Mediated Gene Silencing

被引：96

作者：

Braun, Joerg E. ^{[1
]}

Huntzinger, Eric ^{[1
]}

Izaurralde, Elisa ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, Dept Biochem, D-72076 Tubingen, Germany

来源：

TEN YEARS OF PROGRESS IN GW/P BODY RESEARCH | 2013年 / 768卷

关键词：

MESSENGER-RNA DEADENYLATION; TRANSLATIONAL REPRESSION; AIN-1; INTERACTS; REQUIRES GW182; ARGONAUTE; DOMAINS; IDENTIFICATION; TARGETS; BINDING; MOTIFS;

D O I：

10.1007/978-1-4614-5107-5_9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GW182 family proteins are essential for microRNA-mediated gene silencing in animal cells. They are recruited to miRNA targets through direct interactions with Argonaute proteins and promote target silencing. They do so by repressing translation and enhancing mRNA turnover. Although the precise mechanism of action of GW182 proteins is not fully understood, these proteins have been shown to interact with the cytoplasmic poly(A)-binding protein (PABP) and with the PAN2-PAN3 and CCR4-NOT deadenylase complexes. These findings suggest that GW182 proteins function as scaffold proteins for the assembly of the multiprotein complex that silences miRNA targets.

引用

页码：147 / 163

页数：17

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