Drug-drug salt forms of ciprofloxacin with diflunisal and indoprofen

被引：40

作者：

Bag, Partha Pratim ^{[1
]}

Ghosh, Soumyajit ^{[1
]}

Khan, Hamza ^{[1
]}

Devarapalli, Ramesh ^{[1
]}

Reddy, C. Malla ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Kolkata, Mohanpur 741252, India

来源：

CRYSTENGCOMM | 2014年 / 16卷 / 32期

关键词：

PHARMACEUTICAL COCRYSTAL; SYNTHON TRANSFERABILITY; CRYSTAL-STRUCTURE; CO-CRYSTALS; FAST EVAPORATION; THEOPHYLLINE; NORFLOXACIN; HEXAHYDRATE; POLYMORPHS; SOLVENT;

D O I：

10.1039/c4ce00631c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two salt forms of a fluoroquinolone antibacterial drug, ciprofloxacin (CIP), with non-steroidal anti-inflammatory drugs, diflunisal (CIP/DIF) and indoprofen (CIP/INDP/H2O), were synthesized and characterized by PXRD, FTIR, DSC, TGA and HSM. Crystal structure determination allowed us to study the drug-drug interactions and the piperazine-based synthon (protonated piperazinecarboxylate) in the two forms, which is potentially useful for the crystal engineering of new salt forms of many piperazine-based drugs.

引用

页码：7393 / 7396

页数：4

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