Percutaneous Tibial Nerve Stimulation Produces Effects on Brain Activity: Study on the Modifications of the Long Latency Somatosensory Evoked Potentials

被引:69
作者
Finazzi-Agro, Enrico [1 ,2 ]
Rocchi, Camilla [3 ]
Pachatz, Christa [3 ]
Petta, Filomena [1 ]
Spera, Enrico [1 ,4 ]
Mori, Francesco [3 ]
Sciobica, Francesco [2 ]
Marfia, Girolama A. [3 ]
机构
[1] Univ Roma Tor Vergata, Tor Vergata Univ Hosp, Dept Surg, Chair Urol, I-00133 Rome, Italy
[2] IRCCS, Fdn Santa Lucia, Rome, Italy
[3] Univ Roma Tor Vergata, Tor Vergata Univ Hosp, Dept Neurosci, Chair Neurol, I-00133 Rome, Italy
[4] Policlin Casilino Hosp, Rome, Italy
关键词
long term potentiation; neuromodulation; overactive bladder; percutaneous tibial nerve stimulation; somatosensory evoked potentials; REFRACTORY OVERACTIVE BLADDER; NEUROGENIC BLADDER; NEUROMODULATION;
D O I
10.1002/nau.20651
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective: Long-latency somatosensory evoked potentials (LL-SEP) provide information on the function of somatosensory cortical structures. Percutaneous tibial nerve stimulation (PTNS) is indicated in the treatment of lower urinary tract dysfunction. Aim of this study was to evaluate LL-SEP in patients with overactive bladder syndrome (OAB) treated by means of PTNS. Methods: Sixteen female patients with a diagnosis of pharma-coresistant OAB underwent PTNS while eight female patients with the same diagnosis underwent sham stimulation. LL-SEP were performed at baseline and at the end of PTNS or sham stimulation. Peak latency and peak to peak amplitude of P80, P100, and P200 waves were measured. Results: Mean latency of P80, P100, and P200 and mean amplitude of P200 did not show any significant change after both stimulation. Mean amplitude of P80 and P100 waves increased significantly after PTNS while it did not vary after sham stimulation. Conclusion: The P80 and P100 amplitude increase might reflect long-term modifications in synaptic efficiency through the somatosensory pathway. The plastic reorganization of cortical network triggered by peripheral neuromodulation can be hypothesized as a mechanism of action of PTNS. Further studies are needed to correlate LL-SEP modifications after PTNS with the success of the treatment. Neurourol. Urodynam. 28:320-324, 2009. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码:320 / 324
页数:5
相关论文
共 26 条
[1]   Is pulsed radiofrequency a neuromodulation technique? [J].
Abejón, D ;
Reig, E .
NEUROMODULATION, 2003, 6 (01) :1-3
[2]   Technique of urethral retro-resistance pressure measurement [J].
Abrams, P ;
Cardozo, L .
NEUROUROLOGY AND URODYNAMICS, 2004, 23 (04) :385-385
[3]  
Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052
[4]  
AGAZZI E, 2007, EUR UROL SUPPL, V6, P141
[5]   Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators [J].
Blok, Bertil F. M. ;
Groen, Jan ;
Bosch, J. L. H. Ruud ;
Veltman, Dick J. ;
Lammertsma, Adriaan A. .
BJU INTERNATIONAL, 2006, 98 (06) :1238-1243
[6]   Alterations of cortical electrical activity in patients with sacral neuromodulator [J].
Braun, PM ;
Baezner, H ;
Seif, C ;
Boehler, G ;
Bross, S ;
Eschenfelder, CC ;
Alken, P ;
Hennerici, M ;
Juenemann, P .
EUROPEAN UROLOGY, 2002, 41 (05) :562-566
[7]   Electroacupuncture decreases c-fos expression in the spinal cord induced by noxious stimulation of the rat bladder [J].
Chang, CJ ;
Huang, ST ;
Hsu, K ;
Lin, A ;
Stoller, ML ;
Lue, TF .
JOURNAL OF UROLOGY, 1998, 160 (06) :2274-2279
[8]   LONG-LATENCY SOMATOSENSORY EVOKED-POTENTIALS [J].
COLON, EJ ;
DEWEERD, AW .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1986, 3 (04) :279-296
[9]  
DESMEDT JE, 1981, ORG CEREBRAL CORTEX, P441
[10]   SCALP TOPOGRAPHY OF HUMAN SOMATOSENSORY AND AUDITORY EVOKED-POTENTIALS [J].
GOFF, GD ;
MATSUMIYA, Y ;
ALLISON, T ;
GOFF, WR .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1977, 42 (01) :57-76