Genome-wide Scan of 29,141 African Americans Finds No Evidence of Directional Selection since Admixture

被引：57

作者：

Bhatia, Gaurav ^{[1
,2
]}

Tandon, Arti ^{[2
,3
]}

Patterson, Nick ^{[2
]}

Aldrich, Melinda C. ^{[4
,5
,6
]}

Ambrosone, Christine B. ^{[7
]}

Amos, Christopher ^{[8
]}

Bandera, Elisa V. ^{[9
]}

Berndt, Sonja I. ^{[10
]}

Bernstein, Leslie ^{[11
]}

Blot, William J. ^{[4
,5
,12
]}

Bock, Cathryn H. ^{[13
,14
]}

Caporaso, Neil ^{[10
]}

Casey, Graham ^{[15
,16
]}

Deming, Sandra L. ^{[4
,5
]}

Diver, W. Ryan ^{[17
]}

Gapstur, Susan M. ^{[17
]}

Gillanders, Elizabeth M. ^{[18
]}

Harris, Curtis C. ^{[19
]}

Henderson, Brian E. ^{[15
,16
]}

Ingles, Sue A. ^{[15
,16
]}

Isaacs, William ^{[20
]}

De Jager, Phillip L. ^{[2
,3
,21
]}

John, Esther M. ^{[22
,23
]}

Kittles, Rick A. ^{[24
]}

Larkin, Emma ^{[25
]}

McNeill, Lorna H. ^{[26
,27
]}

Millikan, Robert C. ^{[28
,29
]}

Murphy, Adam ^{[30
]}

Neslund-Dudas, Christine ^{[31
]}

Nyante, Sarah ^{[28
,29
]}

Press, Michael F. ^{[15
,16
]}

Rodriguez-Gil, Jorge L. ^{[32
,33
]}

Rybicki, Benjamin A. ^{[31
]}

Schwartz, Ann G. ^{[13
,14
]}

Signorello, Lisa B. ^{[4
,5
,12
]}

Spitz, Margaret ^{[8
]}

Strom, Sara S. ^{[34
]}

Tucker, Margaret A. ^{[10
]}

Wiencke, John K. ^{[35
]}

Witte, John S. ^{[36
,37
]}

Wu, Xifeng ^{[8
]}

Yamamura, Yuko ^{[34
]}

Zanetti, Krista A. ^{[18
,19
]}

Zheng, Wei ^{[4
,5
]}

Ziegler, Regina G. ^{[10
]}

Chanock, Stephen J. ^{[10
]}

Haiman, Christopher A. ^{[15
,16
]}

Reich, David ^{[2
,3
]}

Price, Alkes L. ^{[2
,38
,39
]}

机构：

[1] Harvard MIT Program Hlth Sci & Technol, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Vanderbilt Epidemiol Ctr, Div Epidemiol, Dept Med, Nashville, TN 37203 USA

[5] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Sch Med, Nashville, TN 37203 USA

[6] Vanderbilt Univ, Dept Thorac Surg, Sch Med, Nashville, TN 37203 USA

[7] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[8] Dartmouth Coll, Geisel Sch Med, Sect Biostat & Epidemiol Community & Family Med, Hanover, NH 03766 USA

[9] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[10] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[11] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA

[12] Int Epidemiol Inst, Rockville, MD 20850 USA

[13] Wayne State Univ Med, Karmanos Canc Inst, Detroit, MI 48201 USA

[14] Wayne State Univ Med, Dept Oncol, Detroit, MI 48201 USA

[15] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[16] Univ So Calif, Keck Sch Med, Dept Pathol, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[17] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA

[18] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[19] NCI, Lab Human Carcinogenesis, Ctr Canc Res, Bethesda, MD 20892 USA

[20] Johns Hopkins Hosp & Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA

[21] Brigham & Womens Hosp, Inst Neurosci, Dept Neurol, Program Translat NeuroPsychiat Genom, Boston, MA 02115 USA

[22] Canc Prevent Inst Calif, Fremont, CA 94538 USA

[23] Stanford Med, Stanford Canc Ctr, Stanford, CA 94305 USA

[24] Univ Illinois, Dept Med, Chicago, IL 60607 USA

[25] Vanderbilt Univ Sch Med, Dept Med, Div Allergy Pulm & Crit Care, Nashville, TN 37232 USA

[26] Univ Texas MD Anderson Canc Ctr, Dept Hlth Dispar Res Canc Prevent & Populat Sci, Houston, TX 77030 USA

[27] Univ Texas MD Anderson Canc Ctr, Duncan Family Inst, Ctr Community Implementat & Disseminat Res, Houston, TX 77030 USA

[28] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA

[29] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[30] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA

[31] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA

[32] Univ Miami, Sylvester Comprehens Canc Ctr, Miller Sch Med, Miami, FL 33136 USA

[33] Univ Miami, Dept Epidemiol & Publ Hlth, Miller Sch Med, Miami, FL 33136 USA

[34] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[35] Univ Calif San Francisco, San Francisco, CA 94158 USA

[36] Univ Calif San Francisco, Inst Human Genet, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA

[37] Univ Calif San Francisco, Inst Human Genet, Dept Urol, San Francisco, CA 94158 USA

[38] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[39] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2014年 / 95卷 / 04期

关键词：

NATURAL-SELECTION; POSITIVE SELECTION; LOCAL-ANCESTRY; ALTITUDE ADAPTATION; GENE; SIGNALS; POPULATIONS; LANDSCAPE; VARIANTS; GO;

D O I：

10.1016/j.ajhg.2014.08.011

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The extent of recent selection in admixed populations is currently an unresolved question. We scanned the genomes of 29,141 African Americans and failed to find any genome-wide-significant deviations in local ancestry, indicating no evidence of selection influencing ancestry after admixture. A recent analysis of data from 1,890 African Americans reported that there was evidence of selection in African Americans after their ancestors left Africa, both before and after admixture. Selection after admixture was reported on the basis of deviations in local ancestry, and selection before admixture was reported on the basis of allele-frequency differences between African Americans and African populations. The local-ancestry deviations reported by the previous study did not replicate in our very large sample, and we show that such deviations were expected purely by chance, given the number of hypotheses tested. We further show that the previous study's conclusion of selection in African Americans before admixture is also subject to doubt. This is because the F-ST statistics they used were inflated and because true signals of unusual allele-frequency differences between African Americans and African populations would be best explained by selection that occurred in Africa prior to migration to the Americas.

引用

页码：437 / 444

页数：8

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