Surface-assisted DNA self-assembly: An enzyme-free strategy towards formation of branched DNA lattice

被引:16
作者
Bhanjadeo, Madhabi M. [1 ,2 ]
Nayak, Ashok K. [1 ]
Subudhi, Umakanta [1 ,2 ]
机构
[1] CSIR, Inst Minerals & Mat Technol, DNA Nanotechnol Applicat Lab, Bhubaneswar 751013, Orissa, India
[2] Acad Sci & Innovat Res AcSIR, New Delhi 110025, India
关键词
DNA nanotechnology; Self-assembly; Aluminum foil; DNA lattice; Nanoelectronics; Y- shaped DNA; ATOMIC-FORCE MICROSCOPY; GRAPHENE OXIDE; ORIGAMI; NANOSTRUCTURES; HYBRIDIZATION; MOLECULES; CRYSTALS; SHAPES; ARRAYS; TILES;
D O I
10.1016/j.bbrc.2017.02.024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA based self-assembled nanostructures and DNA origami has proven useful for organizing nano materials with firm precision. However, for advanced applications like nanoelectronics and photonics, large-scale organization of self-assembled branched DNA (bDNA) into periodic lattices is desired. In this communication for the first time we report a facile method of self-assembly of Y-shaped bDNA nano structures on the cationic surface of Aluminum (Al) foil to prepare periodic two dimensional (2D) bDNA lattice. Particularly those Y-shaped bDNA structures having smaller overhangs and unable to self assemble in solution, they are easily assembled on the surface of Al foil in the absence of ligase. Field emission scanning electron microscopy (FESEM) analysis shows homogenous distribution of two-dimensional bDNA lattices across the Al foil. When the assembled bDNA structures were recovered from the Al foil and electrophoresed in nPAGE only higher order polymeric bDNA structures were observed without a trace of monomeric structures which confirms the stability and high yield of the bDNA lattices. Therefore, this enzyme-free economic and efficient strategy for developing bDNA lattices can be utilized in assembling various nanomaterials for functional molecular components towards development of DNA based self-assembled nanodevices.(C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:492 / 498
页数:7
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