A new cadinane sesquiterpenoid glucoside with cytotoxicity from Abelmoschus sagittifolius

被引：16

作者：

Chen, De-Li ^{[1
,2
]}

Li, Guang ^{[3
,4
]}

Liu, Yang-Yang ^{[1
,2
]}

Ma, Guo-Xu ^{[1
,2
,5
,6
]}

Zheng, Wei ^{[1
,2
]}

Sun, Xiao-Bo ^{[5
,6
]}

Xu, Xu-Dong ^{[5
,6
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Hainan Branch, Hainan Prov Key Lab Resources Conservat & Dev Sou, Wanning, Peoples R China

[2] Peking Union Med Coll, Wanning, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Plant Dev, Yunnan Branch, Xishuangbanna, Peoples R China

[4] Peking Union Med Coll, Xishuangbanna, Peoples R China

[5] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing, Peoples R China

[6] Peking Union Med Coll, Beijing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Abelmoschus sagittifolius; sesquiterpenoid; cytotoxicity;

D O I：

10.1080/14786419.2018.1431635

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new cadinane sesquiterpenoid glucoside, 2 beta,7,3-trihydroxycalamenene 3-O-beta-d-glucoside (1) together with six known compounds, N-(p-trans-coumaroyl)-N-methyl tyramine (2), Cleomiscosin A (3), 9,12,13-trihydroxy-10,15-heptadecadienoic acid (4), Cytochalasin B (5), Marmesinin (6) and N-(p-trans-coumaroyl) tyramine (7) were obtained from the stem bark of Abelmoschus sagittifolius. The new structure of compound 1 was elucidated by analysing its H-1 and C-13-NMR, H-1-H-1 COSY, HSQC, HMBC, NOESY and HR-ESI-MS spectra. Compounds 1-7 showed moderate cytotoxicity against Hela and HepG-2 human cancer cell lines. [GRAPHICS] .

引用

页码：1699 / 1704

页数：6

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