Identification of new medium-chain acylcarnitines present in normal human urine

被引：14

作者：

Libert, R

VanHoof, F

Thillaye, M

Vincent, MF

Nassogne, MC

Stroobant, V

deHoffmann, E

Schanck, A

机构：

[1] UNIV CATHOLIQUE LOUVAIN,CHIM PHYS & CRISTALLOG LAB,B-1348 LOUVAIN,BELGIUM

[2] UNIV CATHOLIQUE LOUVAIN,ADV MAT RES CTR,B-1348 LOUVAIN,BELGIUM

[3] UNIV CATHOLIQUE LOUVAIN,DEPT CHIM,B-1348 LOUVAIN,BELGIUM

来源：

ANALYTICAL BIOCHEMISTRY | 1997年 / 251卷 / 02期

关键词：

D O I：

10.1006/abio.1997.2274

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of urinary medium-chain acylcarnitines extracted on C18 cartridges and gas chromatography mass spectrometry of their fatty acid moieties as picolinyl esters allowed the determination of the chemical structure of previously unidentified acylcarnitines in normal human urine, These are the 2,6-dimethylheptanoyl-, the 2,6-dimethyl-5-heptenoyl-, and the trans- and cis-3,4-methylene heptanoylcarnitines, also named 3-cyclopropane octanoylcarnitines. Assessment of the structure of these cyclopropane. derivatives was obtained by H-1 and C-13 nuclear magnetic resonance spectroscopy, In addition, other acylcarnitines were tentatively identified. (C) 1997 Academic Press.

引用

页码：196 / 205

页数：10

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[11] MASS-SPECTROMETRY METHODS FOR STRUCTURAL DETERMINATION AND ANALYSIS OF FATTY-ACIDS [J].