Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population

被引：9

作者：

Okochi, Tomo ^{[1
]}

Kishi, Taro ^{[1
]}

Ikeda, Masashi ^{[1
]}

Kitajima, Tsuyoshi ^{[1
]}

Kinoshita, Yoko ^{[1
]}

Kawashima, Kunihiro ^{[1
]}

Okumura, Takenori ^{[1
]}

Tsunoka, Tomoko ^{[1
]}

Inada, Toshiya ^{[2
]}

Yamada, Mitsuhiko ^{[3
]}

Uchimura, Naohisa ^{[4
]}

Iyo, Masaomi ^{[5
]}

Sora, Ichiro ^{[6
]}

Ozaki, Norio ^{[7
]}

Ujike, Hiroshi ^{[8
]}

Iwata, Nakao ^{[1
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan

[2] Teikyo Univ, Ichihara Hosp, Dept Psychiat, Ichihara, Chiba, Japan

[3] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Psychogeriatr, Kodaira, Tokyo, Japan

[4] Kurume Univ, Grad Sch Med, Dept Neuropsychiat, Kurume, Fukuoka 830, Japan

[5] Chiba Univ, Dept Psychiat, Grad Sch Med, Chiba, Japan

[6] Tohoku Univ, Dept Psychobiol, Grad Sch Med, Sendai, Miyagi 980, Japan

[7] Nagoya Univ, Dept Psychiat & Psychobiol, Grad Sch Med, Nagoya, Aichi 4648601, Japan

[8] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2009年 / 33卷 / 05期

关键词：

Association study; Methamphetamine-induced psychosis; Neuregulin 1 gene (NRG1); BIPOLAR DISORDER; SCHIZOPHRENIA; NEUREGULIN-1; METAANALYSIS; LINKAGE; CORTEX;

D O I：

10.1016/j.pnpbp.2009.04.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and MEM-induced psychosis in a Japanese population (184 subjects with MEM-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：903 / 905

页数：3

共 15 条

[1] Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex [J].

Abekawa, Tomohiro ;

Ito, Koki ;

Nakagawa, Shin ;

Nakato, Yasuya ;

Koyama, Tsukasa .

SCHIZOPHRENIA RESEARCH, 2008, 101 (1-3) :84-94

[2] The genetic epidemiology of cannabis use, abuse and dependence [J].

Agrawal, Arpana ;

Lynskey, Michael T. .

ADDICTION, 2006, 101 (06) :801-812

[3] Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia [J].

Badner, JA ;

Gershon, ES .

MOLECULAR PSYCHIATRY, 2002, 7 (04) :405-411

[4] Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia [J].

Corfas, G ;

Roy, K ;

Buxbaum, J .

NATURE NEUROSCIENCE, 2004, 7 (06) :575-580

[5] Pedigree disequilibrium tests for multilocus haplotypes [J].

Dudbridge, F .

GENETIC EPIDEMIOLOGY, 2003, 25 (02) :115-121

[6] Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample [J].

Ikeda, Masashi ;

Takahashi, Nagahide ;

Saito, Shinichi ;

Aleksic, Branko ;

Watanabe, Yuichiro ;

Nunokawa, Ayako ;

Yamanouchi, Yoshio ;

Kitajima, Tsuyoshi ;

Kinoshita, Yoko ;

Kishi, Taro ;

Kawashima, Kunihiro ;

Hashimoto, Ryota ;

Ujike, Hiroshi ;

Inada, Toshiya ;

Someya, Toshiyuki ;

Takeda, Masatoshi ;

Ozaki, Norio ;

Iwata, Nakao .

SCHIZOPHRENIA RESEARCH, 2008, 101 (1-3) :1-8

[7]

Jang KL, 1997, ADDICTION, V92, P1265

[8] Alpha4 and Beta2 Subunits of Neuronal Nicotinic Acetylcholine Receptor Genes Are Not Associated with Methamphetamine-Use Disorder in the Japanese Population [J].

Kishi, Taro ;

Ikeda, Masashi ;

Kitajima, Tsuyoshi ;

Yamanouchi, Yoshio ;

Kinoshita, Yoko ;

Kawashima, Kunihiro ;

Inada, Toshiya ;

Harano, Mutsuo ;

Komiyama, Tokutaro ;

Hori, Toru ;

Yamada, Mitsuhiko ;

Iyo, Masaomi ;

Sora, Ichiro ;

Sekine, Yoshimoto ;

Ozaki, Norio ;

Ujike, Hiroshi ;

Iwata, Nakao .

DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES, 2008, 1139 :70-82

[9] Genome scan meta-analysis of schizophrenia and bipolar disorder, part II:: Schizophrenia [J].

Lewis, CM ;

Levinson, DF ;

Wise, LH ;

DeLisi, LE ;

Straub, RE ;

Hovatta, I ;

Williams, NM ;

Schwab, SG ;

Pulver, AE ;

Faraone, SV ;

Brzustowicz, LM ;

Kaufmann, CA ;

Garver, DL ;

Gurling, HMD ;

Lindholm, E ;

Coon, H ;

Moises, HW ;

Byerley, W ;

Shaw, SH ;

Mesen, A ;

Sherrington, R ;

O'Neill, FA ;

Walsh, D ;

Kendler, KS ;

Ekelund, J ;

Paunio, T ;

Lönnqvist, J ;

Peltonen, L ;

O'Donovan, MC ;

Owen, MJ ;

Wildenauer, DB ;

Maier, W ;

Nestadt, G ;

Blouin, JL ;

Antonarakis, SE ;

Mowry, BJ ;

Silverman, JM ;

Crowe, RR ;

Cloninger, CR ;

Tsuang, MT ;

Malaspina, D ;

Harkavy-Friedman, JM ;

Svrakic, DM ;

Bassett, AS ;

Holcomb, J ;

Kalsi, G ;

McQuillin, A ;

Brynjolfson, J ;

Sigmundsson, T ;

Petursson, H .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (01) :34-48

[10] Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits [J].

Purcell, S ;

Cherny, SS ;

Sham, PC .

BIOINFORMATICS, 2003, 19 (01) :149-150

← 1 2 →