Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders

被引：21

作者：

Eggert, Dawn ^{[1
]}

Dash, Prasanta K. ^{[1
]}

Serradji, Nawal ^{[2
]}

Dong, Chang-Zhi ^{[2
]}

Clayette, Pascal ^{[3
]}

Heymans, Francoise ^{[2
]}

Dou, Huanyu ^{[1
]}

Gorantla, Santhi ^{[1
]}

Gelbard, Harris A. ^{[4
,5
,6
,7
]}

Poluektova, Larisa ^{[1
]}

Gendelman, Howard E. ^{[1
,8
]}

机构：

[1] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA

[2] Univ Paris 07, ITODYS Interfaces Truitements Org & Dynam Syst, CNRS, Equipe Pharmacochim Mol,UMR 7086, F-75013 Paris, France

[3] CEA, SPI Bio, Neurovirol Dept, F-92265 Fontenay Aux Roses, France

[4] Univ Rochester, Sch Med & Dent, Ctr Neural Dev & Dis, Rochester, NY 14642 USA

[5] Univ Rochester, Sch Med & Dent, Dept Neurol, Child Neurol Div, Rochester, NY 14642 USA

[6] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA

[7] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA

[8] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 213卷 / 1-2期

关键词：

Platelet activating factor; PMS-601; Human immunodeficiency virus; Multinucleated giant cell; Nuclear factor kappa beta; Proline-rich tyrosine kinase 2; HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; CEREBELLAR GRANULE NEURONS; FOCAL ADHESION KINASE; TNF-ALPHA; SCID MICE; ARACHIDONIC-ACID; IL-10; PRODUCTION; PROTEIN-KINASE; HIV-1-INFECTED MACROPHAGES;

D O I：

10.1016/j.jneuroim.2009.06.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The neutoregulatory activities of PMS-601, a platelet activating factor antagonist, were investigated in laboratory and animal models of HIV-1 encephalitis (HIVE). For the former. PMS-601 reduced monocyte-derived macrophage pro-inflammatory secretions, multinucleated giant cell (MGC) formation, and neuronal loss independent of antiretroviral responses. PMS-601 treatment of HIVE severe combined immunodeficient mice showed reduced microgliosis, MGCs and neurodegeneration. These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：47 / 59

页数：13

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