Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders

被引：21
作者：
Eggert, Dawn [1 ]
Dash, Prasanta K. [1 ]
Serradji, Nawal [2 ]
Dong, Chang-Zhi [2 ]
Clayette, Pascal [3 ]
Heymans, Francoise [2 ]
Dou, Huanyu [1 ]
Gorantla, Santhi [1 ]
Gelbard, Harris A. [4 ,5 ,6 ,7 ]
Poluektova, Larisa [1 ]
Gendelman, Howard E. [1 ,8 ]
机构：
[1] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA
[2] Univ Paris 07, ITODYS Interfaces Truitements Org & Dynam Syst, CNRS, Equipe Pharmacochim Mol,UMR 7086, F-75013 Paris, France
[3] CEA, SPI Bio, Neurovirol Dept, F-92265 Fontenay Aux Roses, France
[4] Univ Rochester, Sch Med & Dent, Ctr Neural Dev & Dis, Rochester, NY 14642 USA
[5] Univ Rochester, Sch Med & Dent, Dept Neurol, Child Neurol Div, Rochester, NY 14642 USA
[6] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA
[7] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA
[8] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 213卷 / 1-2期
关键词：
Platelet activating factor; PMS-601; Human immunodeficiency virus; Multinucleated giant cell; Nuclear factor kappa beta; Proline-rich tyrosine kinase 2; HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; CEREBELLAR GRANULE NEURONS; FOCAL ADHESION KINASE; TNF-ALPHA; SCID MICE; ARACHIDONIC-ACID; IL-10; PRODUCTION; PROTEIN-KINASE; HIV-1-INFECTED MACROPHAGES;
D O I：
10.1016/j.jneuroim.2009.06.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The neutoregulatory activities of PMS-601, a platelet activating factor antagonist, were investigated in laboratory and animal models of HIV-1 encephalitis (HIVE). For the former. PMS-601 reduced monocyte-derived macrophage pro-inflammatory secretions, multinucleated giant cell (MGC) formation, and neuronal loss independent of antiretroviral responses. PMS-601 treatment of HIVE severe combined immunodeficient mice showed reduced microgliosis, MGCs and neurodegeneration. These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：47 / 59
页数：13
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