Association between serum uric acid and bone health in general population: a large and multicentre study

被引：26

作者：

Lin, Xianfeng ^{[1
]}

Zhao, Chenchen ^{[1
]}

Qin, An ^{[2
]}

Hong, Dun ^{[3
]}

Liu, Wenyue ^{[4
]}

Huang, Kangmao ^{[1
]}

Mo, Jian ^{[1
]}

Yu, Hejun ^{[1
]}

Wu, Shengjie ^{[5
]}

Fan, Shunwu ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Orthoped Surg, Hangzhou 310003, Zhejiang, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Orthoped,Shanghai Key Lab Orthoped Implant, Shanghai 200030, Peoples R China

[3] Wenzhou Med Univ, Taizhou Hosp, Dept Orthoped Surg, Linhai, Peoples R China

[4] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou, Peoples R China

[5] Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Cardiovasc Dis Wenzhou, Dept Cardiol, Wenzhou, Peoples R China

来源：

ONCOTARGET | 2015年 / 6卷 / 34期

基金：

中国国家自然科学基金;

关键词：

serum uric acid; bone health; bone mineral density; bone mass loss; DXA; Gerotarget; GLOMERULAR-FILTRATION-RATE; MINERAL DENSITY; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS; FEMALE SUBJECTS; DISEASE; HYPERURICEMIA; HYPERTENSION; EQUATION; RISK;

D O I：

10.18632/oncotarget.6173

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous studies proposed that serum uric acid (UA), an endogenous antioxidant, could be a protective factor against bone loss. However, recently, a study with a population of US adults did not note the protective effects of serum UA. Therefore, the exact association between serum UA and bone health remains unclear. We performed a retrospective consecutive cohort study in a Chinese population to examine the association between serum UA and bone health. This cross-sectional study included 17,735 individuals who underwent lumbar spine bone mineral density (BMD) measurements as part of a health examination. In covariance analyses (multivariable-adjusted), a high serum UA level was associated with a high BMD, T-score, and Z-score. In binary logistic regression analyses (multivariable-adjusted), a high serum UA level was associated with low odds ratios (ORs) for at least osteopenia and osteoporosis in male (age >= 50 years) (OR = 0.72-0.60 and OR = 0.49-0.39, respectively) and postmenopausal female participants (OR = 0.61-0.51 and OR = 0.66-0.49, respectively). In conclusion, serum UA is associated with BMD, the T-score, and the Z-score, and has a strong protective effect against at least osteopenia and osteoporosis.

引用

页码：35395 / 35403

页数：9

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