Csp2-O and C-C Bond Formation via Pd-Catalyzed Coupling Reaction of 2,4-Dichloroquinazoline

被引：0

作者：

Sharma, Alka ^{[1
]}

Luxami, Vijay ^{[1
]}

Paul, Kamaldeep ^{[1
]}

机构：

[1] Thapar Univ, Sch Chem & Biochem, Patiala 147004, Punjab, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 53卷 / 01期

关键词：

ARYL HALIDES; QUINAZOLINONE DERIVATIVES; HETEROARYL CHLORIDES; KINASE INHIBITORS; CASCADE SYNTHESIS; SOLVENT-FREE; PALLADIUM; HYDROXYLATION; DISCOVERY; POTENT;

D O I：

10.1002/jhet.2330

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium-catalyzed C-O and subsequent C-C bond formation of 2,4-dichloroquinazoline have been described. The designed strategy results in the synthesis of novel 2-arylated quinazolin-4-ones framework with various aryl/heteroaryl boronic acids in moderate to good yields along with 2,4-diarylated quinazolines. This methodology offers a direct transformation of aryl halides to aryl alcohols/ketone as well as the straight forward application to generate a wide variety of monoaryl and diaryl quinazoline.

引用

页码：241 / 248

页数：8

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