Domain Fishing: a first step in protein comparative modelling

被引：132
作者：
Contreras-Moreira, B [1 ]
Bates, PA [1 ]
机构：
[1] Lincolns Inn Fields Labs, Canc Res UK London Res Inst, Biomol Modelling Lab, London WC2A 3PX, England
来源：
BIOINFORMATICS | 2002年 / 18卷 / 08期
关键词：
D O I：
10.1093/bioinformatics/18.8.1141
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
To optimize the search for structural templates in protein comparative modelling, the query sequence is split into domains. The initial list of templates for each domain, extracted from PFAM plus PDB and SCOP, is then ranked according to sequence identity (%ID), coverage and resolution. If %ID is less than 30, secondary structure matching is used to filter out false templates.
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页码：1141 / 1142
页数：2
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