Sarcoma-The standard-bearer in cancer discovery

被引：29

作者：

Potter, Jared W. ^{[1
]}

Jones, Kevin B. ^{[1
]}

Barrott, Jared J. ^{[2
]}

机构：

[1] Univ Utah, Dept Orthopaed, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[2] Idaho State Univ, Dept Biomed & Pharmaceut Sci, Pocatello, ID 83209 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2018年 / 126卷

关键词：

Sarcoma; Immunotherapy; Epigenetics; Mutational burden; Chemoresistance; SOFT-TISSUE SARCOMA; GASTROINTESTINAL STROMAL TUMORS; SYNOVIAL SARCOMA; FAMILIAL SYNDROME; CLINICAL-TRIALS; BREAST-CANCER; IMMUNOTHERAPY; FUSION; HETEROGENEITY; CHEMOTHERAPY;

D O I：

10.1016/j.critrevonc.2018.03.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sarcoma is a rare tumor type that occurs most frequently in connective tissue. Despite its uncommon occurrence, sarcoma research has provided the means for groundbreaking research that has advanced our understanding of general cancer mechanisms. It is through sarcoma research that the pioneering efforts of cancer immunotherapy were explored, that we understand the inherent genetic nature of cancer mutations, and that we appreciate the subclassification of general cancer types to make more accurate prognoses. This review explores the brief history of sarcoma research and what sarcomas can still teach us about the future of cancer research, especially in regard to novel immunotherapy targets, the role of epigenetics in disease progression and chemoresistance, and the benefits of more focused clinical trials.

引用

页码：1 / 5

页数：5

共 45 条

[1] The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis [J].

Barrott, Jared J. ;

Zhu, Ju-Fen ;

Smith-Fry, Kyllie ;

Susko, Asia M. ;

Nollner, Dakota ;

Burrell, Lance D. ;

Pozner, Amir ;

Capecchi, Mario R. ;

Yap, Jeffrey T. ;

Cannon-Albright, Lisa A. ;

Deng, Xingming ;

Jones, Kevin B. .

MOLECULAR CANCER RESEARCH, 2017, 15 (12) :1733-1740

[2] Modeling synovial sarcoma metastasis in the mouse: PI3′-lipid signaling and inflammation [J].

Barrott, Jared J. ;

Kafchinski, Lisa A. ;

Jin, Huifeng ;

Potter, Jared W. ;

Kannan, Sarmishta D. ;

Kennedy, Robert ;

Mosbruger, Tim ;

Wang, Wei-Lien ;

Tsai, Jen-Wei ;

Araujo, Dejka M. ;

Liu, Ting ;

Capecchi, Mario R. ;

Lazar, Alexander J. ;

Jones, Kevin B. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (13) :2989-3005

[3]

Baudino Troy A, 2015, Curr Drug Discov Technol, V12, P3

[4] Discovery of oncogenes: The advent of molecular cancer research [J].

Bister, Klaus .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (50) :15259-15260

[5] THE ROLE OF MULTIMODALITY THERAPY IN SOFT-TISSUE SARCOMA [J].

BRENNAN, MF ;

CASPER, ES ;

HARRISON, LB ;

SHIU, MH ;

GAYNOR, J ;

HAJDU, SI .

ANNALS OF SURGERY, 1991, 214 (03) :328-338

[6] The role of cytogenetics and molecular diagnostics in the diagnosis of soft-tissue tumors [J].

Bridge, Julia A. .

MODERN PATHOLOGY, 2014, 27 :S80-S97

[7]

Camidge D Ross, 2014, Clin Adv Hematol Oncol, V12, P763

[8] Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden [J].

Chalmers, Zachary R. ;

Connelly, Caitlin F. ;

Fabrizio, David ;

Gay, Laurie ;

Ali, Siraj M. ;

Ennis, Riley ;

Schrock, Alexa ;

Campbell, Brittany ;

Shlien, Adam ;

Chmielecki, Juliann ;

Huang, Franklin ;

He, Yuting ;

Sun, James ;

Tabori, Uri ;

Kennedy, Mark ;

Lieber, Daniel S. ;

Roels, Steven ;

White, Jared ;

Otto, Geoffrey A. ;

Ross, Jeffrey S. ;

Garraway, Levi ;

Miller, Vincent A. ;

Stephens, Phillip J. ;

Frampton, Garrett M. .

GENOME MEDICINE, 2017, 9

[9] Soft Tissue Sarcoma [J].

Demetri, George D. ;

Antonia, Scott ;

Benjamin, Robert S. ;

Bui, Marilyn M. ;

Casper, Ephraim S. ;

Conrad, Ernest U., III ;

DeLaney, Thomas F. ;

Ganjoo, Kristen N. ;

Heslin, Martin J. ;

Hutchinson, Raymond J. ;

Kane, John M., III ;

Letson, G. Douglas ;

McGarry, Sean V. ;

O'Donnell, Richard J. ;

Paz, I. Benjamin ;

Pfeifer, John D. ;

Pollock, Raphael E. ;

Randall, R. Lor ;

Riedel, Richard F. ;

Schupak, Karen D. ;

Schwartz, Herbert S. ;

Thornton, Katherine ;

von Mehren, Margaret ;

Wayne, Jeffrey .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2010, 8 (06) :630-674

[10] Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy [J].

Diaz-Montero, C. Marcela ;

Salem, Mohamed Labib ;

Nishimura, Michael I. ;

Garrett-Mayer, Elizabeth ;

Cole, David J. ;

Montero, Alberto J. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (01) :49-59

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