Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead

被引：34

作者：

Borody, Thomas ^{[1
]}

Fischer, Monika ^{[2
]}

Mitchell, Scott ^{[1
]}

Campbell, Jordana ^{[1
]}

机构：

[1] Ctr Digest Dis, Five Dock, NSW 2046, Australia

[2] Indiana Univ, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2015年 / 9卷 / 11期

关键词：

antibiotic resistance; fecal microbiota transplantation; FMT; FSM; full spectrum microbiota; microbiome; probiotics; CLOSTRIDIUM-DIFFICILE INFECTION; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL MICROBIOTA; ULCERATIVE-COLITIS; TOXIC MEGACOLON; DONOR FECES; STOOL; BACTERIOTHERAPY; DIARRHEA; TRIAL;

D O I：

10.1586/17474124.2015.1086267

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

At its height, the Clostridium difficile infection epidemic caused approximately 7000 infections and 300 deaths per day in the USA. Fecal microbiota transplantation (FMT) has demonstrated extraordinary clinical resolution, C. difficile infection cure rates of over 90%, and low recurrence. In tandem with the rise of FMT, the gastrointestinal microbiome has emerged as a vital' organ armed with a wealth of microbe soldiers' more powerful than known antibiotics. FMTs' reputation has diffused into many new indications' yet these appear to be merely the tip of the iceberg when considering its potential applications. FMT as a therapeutic tool has evolved from the original format of blended donor stool and moved towards a refined product comprising a myriad of microbial components, presented aesthetically as encapsulated lyophilized powder.

引用

页码：1379 / 1391

页数：13

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