Value of cerebrospinal fluid -synuclein species as biomarker in Parkinson's diagnosis and prognosis

被引：52
作者：
Parnetti, Lucilla [1 ]
Cicognola, Claudia [2 ]
Eusebi, Paolo [1 ,3 ]
Chiasserini, Davide [1 ]
机构：
[1] Univ Perugia, Neurol Sect, Dept Med, Ctr Memory Disturbances, I-06132 Perugia, Italy
[2] Univ Gothenburg, Clin Neurochem Lab, Inst Neurosci & Physiol, Dept Psychiat & Neurochem,Sahlgrenska Acad, Molndal, Sweden
[3] Hlth Planning Serv, Reg Hlth Author Umbria, Dept Epidemiol, Perugia, Italy
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期
关键词：
alpha-synuclein; cerebrospinal fluid biomarkers; cognitive impairment; disease progression; early diagnosis; motor symptoms; parkinsonisms; Parkinson's disease; prognosis; CSF ALPHA-SYNUCLEIN; MULTIPLE SYSTEM ATROPHY; DRUG-NAIVE PATIENTS; ELEVATED LEVELS; MONOCLONAL-ANTIBODIES; LEWY BODIES; DISEASE; DEMENTIA; ALZHEIMERS; QUANTIFICATION;
D O I：
10.2217/bmm.15.107
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Since diagnosis of Parkinson's disease (PD) is mostly based on clinical criteria, it is almost impossible to formulate an early diagnosis, as well as a timely differential diagnosis versus other parkinsonisms. A great effort in searching reliable biomarkers both for early diagnosis and prognosis in PD is currently ongoing. Cerebrospinal fluid has been widely investigated as potential source for such biomarkers, with particular emphasis on -synuclein (-syn) species. We reviewed all the clinical studies carried out so far on cerebrospinal fluid quantification of -syn species in PD. Current evidence supports the value of total and oligomeric -syn in PD diagnosis and in the differential diagnosis of PD and other parkinsonisms. Conversely, the role of -syn species in PD prognosis remains unsatisfactory.
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收藏
页码：35 / 49
页数：15
相关论文
共 52 条
[1]   Prevalence and characteristics of dementia in Parkinson disease - An 8-year prospective study [J].
Aarsland, D ;
Andersen, K ;
Larsen, JP ;
Lolk, A ;
Kragh-Sorensen, P .
ARCHIVES OF NEUROLOGY, 2003, 60 (03) :387-392
[2]   Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers [J].
Aasly, Jan O. ;
Johansen, Krisztina K. ;
Bronstad, Gunnar ;
Waro, Bjorg J. ;
Majbour, Nour K. ;
Varghese, Shiji ;
Alzahmi, Fatimah ;
Paleologou, Katerina E. ;
Amer, Dena A. M. ;
Al-Hayani, Abdulmonem ;
El-Agnaf, Omar M. A. .
FRONTIERS IN AGING NEUROSCIENCE, 2014, 6
[3]   CSF α-synuclein does not differentiate between parkinsonian disorders [J].
Aerts, M. B. ;
Esselink, R. A. J. ;
Abdo, W. F. ;
Bloem, B. R. ;
Verbeek, M. M. .
NEUROBIOLOGY OF AGING, 2012, 33 (02) :430.e1-430.e3
[4]   Genomic and Pharmacogenomic Biomarkers of Parkinson's Disease [J].
Alonso-Navarro, Hortensia ;
Javier Jimenez-Jimenez, Felix ;
Garcia-Martin, Elena ;
Agundez, Jose A. G. .
CURRENT DRUG METABOLISM, 2014, 15 (02) :129-181
[5]   Novel One-step Immunoassays to Quantify α-Synuclein APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING [J].
Bidinosti, Michael ;
Shimshek, Derya R. ;
Mollenhauer, Brit ;
Marcellin, David ;
Schweizer, Tatjana ;
Lotz, Gregor P. ;
Schlossmacher, Michael G. ;
Weiss, Andreas .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (40) :33691-33705
[6]   Full length α-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects [J].
Borghi, R ;
Marchese, R ;
Negro, A ;
Marinelli, L ;
Forloni, G ;
Zaccheo, D ;
Abbruzzese, G ;
Tabaton, M .
NEUROSCIENCE LETTERS, 2000, 287 (01) :65-67
[7]   Correlation between decreased CSF α-synuclein and Aβ1-42 in Parkinson disease [J].
Buddhala, Chandana ;
Campbell, Meghan C. ;
Perlmutter, Joel S. ;
Kotzbauer, Paul T. .
NEUROBIOLOGY OF AGING, 2015, 36 (01) :476-484
[8]   Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease [J].
Compta, Yaroslau ;
Valente, Tony ;
Saura, Josep ;
Segura, Barbara ;
Iranzo, Alex ;
Serradell, Monica ;
Junque, Carme ;
Tolosa, Eduard ;
Valldeoriola, Francesc ;
Munoz, Esteban ;
Santamaria, Joan ;
Camara, Ana ;
Fernandez, Manel ;
Fortea, Juan ;
Buongiorno, Mariateresa ;
Luis Molinuevo, Jose ;
Bargallo, Nuria ;
Jose Marti, Maria .
JOURNAL OF NEUROLOGY, 2015, 262 (02) :294-306
[9]  
del Campo M, 2012, BIOMARK MED, V6, P419, DOI [10.2217/BMM.12.46, 10.2217/bmm.12.46]
[10]   α-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma [J].
El-Agnaf, OMA ;
Salem, SA ;
Paleologou, KE ;
Cooper, LJ ;
Fullwood, NJ ;
Gibson, MJ ;
Curran, MD ;
Court, JA ;
Mann, DMA ;
Ikeda, S ;
Cookson, MR ;
Hardy, J ;
Allsop, D .
FASEB JOURNAL, 2003, 17 (11) :1945-+
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