Proton magnetic resonance spectroscopy of skeletal muscle: A comparison of two quantitation techniques

被引:16
作者
Wang, Xin [1 ]
Salibi, Nouha [2 ]
Fayad, Laura M. [3 ]
Barker, Peter B. [3 ,4 ]
机构
[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10021 USA
[2] Siemens Med Solut, Malvern, PA 19355 USA
[3] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA
[4] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD 21205 USA
关键词
MR spectroscopy; Muscle; Quantitation; Phantom replacement; ABSOLUTE METABOLITE CONCENTRATIONS; MR SPECTROSCOPY; HUMAN BRAIN; 3; T; WATER-SUPPRESSION; ERETIC METHOD; QUANTIFICATION; FEASIBILITY; CARNOSINE; COILS;
D O I
10.1016/j.jmr.2014.03.010
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Rationale and objectives: The aim of this study was to develop and compare two methods for quantification of metabolite concentrations in human skeletal muscle using phased-array receiver coils at 3 T. Materials and methods: Water suppressed and un-suppressed spectra were recorded from the quadriceps muscle (vastus medialis) in 8 healthy adult volunteers, and from a calibration phantom containing 69 mM/L N-acetyl aspartate. Using the phantom replacement technique, trimethylamine specifically [TMA] and creatine [Cr] concentrations were estimated, and compared to those values obtained by using the water reference method. Results: Quadriceps [TMA] concentrations were 9.5 +/- 2.4 and 9.6 +/- 4.1 mmol/kg wet weight using the phantom replacement and water referencing methods respectively, while [Cr] concentrations were 26.8 +/- 12.2 and 24.1 +/- 5.3 mmol/kg wet weight respectively. Conclusions: Reasonable agreement between water referencing and phantom replacement methods was found, although for [Cr] variation was significantly higher for the phantom replacement technique. The relative advantages and disadvantages of each approach are discussed. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:81 / 84
页数:4
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