Evaluation of CCL5-403 G>A and CCR5 Δ32 gene polymorphisms in patients with breast cancer

被引:16
作者
Eskandari-Nasab, Ebrahim [1 ,2 ]
Hashemi, Mohammad [2 ]
Ebrahimi, Mahboubeh [2 ]
Amininia, Shadi [2 ]
Bahari, Gholamreza [2 ]
Mashhadi, Mohammad-Ali [3 ]
Taheri, Mohsen [4 ]
机构
[1] Zahedan Univ Med Sci, Genet Noncommunicable Dis Res Ctr, Zahedan, Iran
[2] Zahedan Univ Med Sci, Sch Med, Dept Clin Biochem, Zahedan, Iran
[3] Zahedan Univ Med Sci, Sch Med, Dept Internal Med, Zahedan, Iran
[4] Zahedan Univ Med Sci, Sch Med, Dept Genet, Zahedan, Iran
关键词
CCL5; CCR5; breast cancer; gene polymorphism; HEPATOCELLULAR-CARCINOMA OCCURRENCE; CHEMOATTRACTANT PROTEIN-1 MCP-1; GAMMA INDUCIBLE CHEMOKINES; PROSTATE-CANCER; CLINICOPATHOLOGICAL CHARACTERISTICS; TNF-A; ASSOCIATION; RECEPTOR; RANTES; EXPRESSION;
D O I
10.3233/CBM-140411
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Recent evidence has demonstrated the implication of CC chemokine ligand 5 (CCL5) and CC chemokine receptor 5 (CCR5) in breast tumor initiation and progression. OBJECTIVE: The purpose of this study was to investigate whether single nucleotide polymorphisms of CCL5 -403 G>A (rs2107538) and CCR5 Delta 32 genes are associated with the breast cancer (BC) risk. METHODS: A total of 439 subjects including on 236 BC patients and 203 healthy controls from the same area were recruited. The CCL5 -403 G>A and CCR5 Delta 32 polymorphisms were genotyped by allele-specific polymerase chain reaction (AS-PCR) and PCR, respectively. RESULTS: Our data demonstrated that the CCL5 -403 GA and GA+AA genotypes, with a higher frequency in the BC patients compared to the control group, were associated with an increased risk of BC in the codominant (GG vs. GA OR = 1.75, 95% CI = 1.07-2.86, P = 0.025) and dominant models (GG vs. GA+AA: OR = 1.84, 95% CI = 1.15-2.93, P = 0.014), respectively. Additionally, the A allele of CCL5 -403 G>A variation was found more prevalent in the BC patients than in controls (14% vs. 8%) and was a risk factor for BC (G vs. A: OR = 1.87, 95% CI = 1.21-2.89, P = 0.004). CONCLUSIONS: Our findings highlighted that the CCL5 -403 G>A polymorphism is a risk factor for BC in our population. Our findings suggest that the CCL5 -403 GA and GA+AA genotypes and the A allele were associated with an elevated risk of BC which may function as risk factor for breast carcinoma.
引用
收藏
页码:343 / 351
页数:9
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