State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

被引：6

作者：

Mukhina, A. Yu. ^{[1
]}

Medvedeva, O. A. ^{[1
]}

Svishcheva, M. V. ^{[1
]}

Shevchenko, A. V. ^{[1
]}

Efremova, N. N. ^{[1
]}

Bobyntsev, I. I. ^{[1
]}

Kalutskii, P. V. ^{[1
]}

Andreeva, L. A. ^{[2
]}

Myasoedov, N. F. ^{[2
]}

机构：

[1] Kursk State Med Univ, Minist Hlth Russian Federat, Kursk, Russia

[2] Russian Acad Sci, Inst Mol Genet, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 167卷 / 02期

关键词：

Selank; restraint stress; microbiota; dysbiosis;

D O I：

10.1007/s10517-019-04496-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 mu g/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.

引用

页码：226 / 228

页数：3

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