Rev: beyond nuclear export

被引：53

作者：

Groom, H. C. T. ^{[1
]}

Anderson, E. C. ^{[2
]}

Lever, A. M. ^{[1
]}

机构：

[1] Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

[2] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England

来源：

JOURNAL OF GENERAL VIROLOGY | 2009年 / 90卷

基金：

英国医学研究理事会;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTIOUS-ANEMIA VIRUS; TRANSLATION INITIATION-FACTOR; DOMINANT-NEGATIVE MUTANTS; VIRAL MESSENGER-RNA; NUCLEOPORIN-LIKE PROTEIN; HIV-1 PACKAGING SIGNAL; SRC-ASSOCIATED PROTEIN; RESPONSE ELEMENT RNA; CIS-ACTING SEQUENCES;

D O I：

10.1099/vir.0.011460-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rev remains a hot topic. In this review, we revisit the insights that have been gained into the control of gene expression by the retroviral protein Rev and speculate on where current research is leading. We outline what is known about the role of Rev in translation and encapsidation and how these are linked to its more traditional role of nuclear export, underlining the multifaceted nature of this small viral protein. We discuss what more is to be learned in these fields and why continuing research on these 116 amino acids and understanding their function is still important in devising methods to combat AIDS.

引用

页码：1303 / 1318

页数：16

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