Synthesis and anti-microbial activity of pyrazolylbisindoles - Promising anti-fungal compounds

被引：169
作者：
Sivaprasad, Ganesabaskaran
Perumal, Paramasivan T. [1 ]
Prabavathy, Vaiyapurl R.
Mathivanan, Narayanasamy
机构：
[1] Cent Leather Res Inst, Organ Chem Div, Madras 600020, Tamil Nadu, India
[2] Univ Madras, Ctr Adv Studies Bot, Madras 600025, Tamil Nadu, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 24期
关键词：
pyrazolylbisindoles; anti-microbial screening; plant pathogenic fungi; human pathogenic bacteria;
D O I：
10.1016/j.bmcl.2006.09.019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of pyrazolylbisindole derivatives have been synthesized by reacting substituted pyrazole aldehydes with substituted indoles using phosphotungstic acid, a Keggin type heteropoly acid as catalyst. The synthesized pyrazolylbisindoles were evaluated for anti-microbial activities. The effect of pyrazolylbisindoles on the mycelial growth of plant pathogenic fungi is revealed. Entries 3c and 3d emerged as the most interesting compounds in this series exhibiting excellent anti-fungal activity. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：6302 / 6305
页数：4
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