Synthesis of Nanoparticles of Star-shaped Mannitol-core PLA-TPGS Copolymer for Delivery of Paclitaxel and Activity of Anti-prostate Cancer
被引:4
作者:
Wang Hai
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机构:
Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R ChinaChinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Wang Hai
[1
,2
]
Zhang Chao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R ChinaChinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Zhang Chao
[1
,2
]
Zhang Linhua
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R ChinaChinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Zhang Linhua
[1
,2
]
Liu Lanxia
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R ChinaChinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Liu Lanxia
[1
,2
]
Zheng Yi
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R ChinaChinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Zheng Yi
[3
]
Zhu Dunwan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R ChinaChinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Zhu Dunwan
[1
,2
]
机构:
[1] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
[2] Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R China
[3] Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
来源:
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
|
2014年
/
35卷
/
10期
The objective of this research is to fabricate novel nanoparticles (NPs) of star-shaped mannitol-functionalized polylactic acid-D-alpha-tocopheryl polyethylene glycol 1000 suclinat(PLA-TPGS) copolymer for paclitaxel delivery for prostate cancer treatment, and evaluate their therapeutic effects in prostate cancer cell line in comparison with the linear PLGA NPs and PLA-TPGS NPs. The paclitaxel-loaded M-PLA-TPGS NPs, prepared by a modified nano-precipitation method, were observed by field emission scanning electron microscopy (FESEM) to be near-spherical shape with narrow size distribution. The drug-loaded NPs were further characterized in terms of size, surface charge, drug content, encapsulation efficiency and in vitro drug release. In vitro drug release exhibited biphasic pattern with initial burst release followed by slow and continuous release. The cellular uptake level of M-PLA-TPGS NPs was demonstrated higher than linear PLGA NPs and PLA-TPGS NPs in PC-3 cells. The data also showed that the paclitaxel-loaded M-PLA-TPGS nanoparticles have higher antitumor efficacy than that of linear PLA-TPGS nanoparticles and commercial Taxol in vitro. The star-shaped copolymer M-PLA-TPGS could be used as a potential and promising molecular biomaterial applied in developing novel nanoformulation for prostate cancer treatment.
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Huang, Laiqiang
Chen, Hongbo
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Chen, Hongbo
Zheng, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Zheng, Yi
Song, Xiaosong
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Song, Xiaosong
Liu, Ranyi
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Liu, Ranyi
Liu, Kexin
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Pharm, Dalian 116027, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Liu, Kexin
Zeng, Xiaowei
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R China
Northeastern Univ, Dept Mat Sci & Engn, Qinhuangdao Branch, Qinhuangdao 066004, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Zeng, Xiaowei
Mei, Lin
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R China
Dalian Med Univ, Coll Pharm, Dalian 116027, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Ikeda, M
Bhattacharjee, AK
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Bhattacharjee, AK
Kondoh, T
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Kondoh, T
Nagashima, T
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Nagashima, T
Tamaki, N
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
机构:
Univ Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, ItalyUniv Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, Italy
Maglio, G
Nese, G
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, ItalyUniv Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, Italy
Nese, G
Nuzzo, M
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, ItalyUniv Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, Italy
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Huang, Laiqiang
Chen, Hongbo
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Chen, Hongbo
Zheng, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Zheng, Yi
Song, Xiaosong
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Song, Xiaosong
Liu, Ranyi
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Liu, Ranyi
Liu, Kexin
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Pharm, Dalian 116027, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Liu, Kexin
Zeng, Xiaowei
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R China
Northeastern Univ, Dept Mat Sci & Engn, Qinhuangdao Branch, Qinhuangdao 066004, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Zeng, Xiaowei
Mei, Lin
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Gene & Antibody Therapy, Shenzhen 518055, Guangdong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518055, Guangdong, Peoples R China
Dalian Med Univ, Coll Pharm, Dalian 116027, Peoples R ChinaTsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Ikeda, M
Bhattacharjee, AK
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Bhattacharjee, AK
Kondoh, T
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Kondoh, T
Nagashima, T
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
Nagashima, T
Tamaki, N
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan
机构:
Univ Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, ItalyUniv Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, Italy
Maglio, G
Nese, G
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, ItalyUniv Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, Italy
Nese, G
Nuzzo, M
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, ItalyUniv Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Chim, I-80126 Naples, Italy