Synthesis of Nanoparticles of Star-shaped Mannitol-core PLA-TPGS Copolymer for Delivery of Paclitaxel and Activity of Anti-prostate Cancer

被引:4
作者
Wang Hai [1 ,2 ]
Zhang Chao [1 ,2 ]
Zhang Linhua [1 ,2 ]
Liu Lanxia [1 ,2 ]
Zheng Yi [3 ]
Zhu Dunwan [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
[2] Peking Union Med Coll, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R China
[3] Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
来源
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2014年 / 35卷 / 10期
基金
中国国家自然科学基金;
关键词
Star-shaped copolymer; Paclitaxel; Polylactic acid; Poly (lactic-co-glycolic acid); Nanoparticles; Drug delivery; Cancer nanotechnology; Prostate cancer; Cytotoxicity; BLOOD-BRAIN-BARRIER; DRUG-DELIVERY; BREAST-CANCER; NANOMEDICINE; POLYMERS;
D O I
10.7503/cjcu20140504
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The objective of this research is to fabricate novel nanoparticles (NPs) of star-shaped mannitol-functionalized polylactic acid-D-alpha-tocopheryl polyethylene glycol 1000 suclinat(PLA-TPGS) copolymer for paclitaxel delivery for prostate cancer treatment, and evaluate their therapeutic effects in prostate cancer cell line in comparison with the linear PLGA NPs and PLA-TPGS NPs. The paclitaxel-loaded M-PLA-TPGS NPs, prepared by a modified nano-precipitation method, were observed by field emission scanning electron microscopy (FESEM) to be near-spherical shape with narrow size distribution. The drug-loaded NPs were further characterized in terms of size, surface charge, drug content, encapsulation efficiency and in vitro drug release. In vitro drug release exhibited biphasic pattern with initial burst release followed by slow and continuous release. The cellular uptake level of M-PLA-TPGS NPs was demonstrated higher than linear PLGA NPs and PLA-TPGS NPs in PC-3 cells. The data also showed that the paclitaxel-loaded M-PLA-TPGS nanoparticles have higher antitumor efficacy than that of linear PLA-TPGS nanoparticles and commercial Taxol in vitro. The star-shaped copolymer M-PLA-TPGS could be used as a potential and promising molecular biomaterial applied in developing novel nanoformulation for prostate cancer treatment.
引用
收藏
页码:2239 / 2245
页数:7
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