Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance

被引：106

作者：

Jenkins, Benjamin J. ^{[1
]}

Seyssel, Kevin ^{[2
,3
]}

Chiu, Sally ^{[4
]}

Pan, Pin-Ho ^{[5
]}

Lin, Shih-Yi ^{[6
]}

Stanley, Elizabeth ^{[1
]}

Ament, Zsuzsanna ^{[1
]}

West, James A. ^{[1
]}

Summerhill, Keith ^{[1
]}

Griffin, Julian L. ^{[1
]}

Vetter, Walter ^{[7
]}

Autio, Kaija J. ^{[8
]}

Hiltunen, Kalervo ^{[8
]}

Hazebrouck, Stephane ^{[9
]}

Stepankova, Renata ^{[10
]}

Chen, Chun-Jung ^{[11
]}

Alligier, Maud ^{[2
,3
]}

Laville, Martine ^{[2
,3
]}

Moore, Mary ^{[12
]}

Kraft, Guillaume ^{[12
]}

Cherrington, Alan ^{[12
]}

King, Sarah ^{[4
]}

Krauss, Ronald M. ^{[4
]}

de Schryver, Evelyn ^{[13
]}

Van Veldhoven, Paul P. ^{[13
]}

Ronis, Martin ^{[14
]}

Koulman, Albert ^{[1
,15
]}

机构：

[1] Univ Cambridge, Med Res Council Human Nutr Res, Elsie Widdowson Lab, Fulbourn Rd, Cambridge CB1 9NL, England

[2] Lyon Univ, INSERM, CarMeN Lab, U1060, F-69310 Pierre Benite, France

[3] Univ Lyon 1, Ctr Hosp Lyon Sud, CRNH Rhone Alpes, CENS, F-69310 Pierre Benite, France

[4] Childrens Hosp, Oakland Res Inst, 5700 Martin Luther King Jr Way, Oakland, CA 94609 USA

[5] Tungs Taichung MetroHarbor Hosp, Dept Pediat, Taichung 435, Taiwan

[6] Taichung Vet Gen Hosp, Ctr Geriatr & Gerontol, Div Endocrinol & Metab, 1650 Sec 4,Taiwan Blvd, Taichung 407, Taiwan

[7] Univ Hohenheim, Inst Food Chem, Garbenstr 28, D-70599 Stuttgart, Germany

[8] Univ Oulu, Bioctr Oulu, Fac Biochem & Mol Med, POB 5400, FI-90014 Oulu, Finland

[9] Univ Paris Saclay, UMR CEA INRA Serv Pharmacol & Immunoanal, Lab Immuno Allergie Alimentaire, F-91991 Gif Sur Yvette, France

[10] Czech Acad Sci, Inst Microbiol, Lab Gnotobiol, Prague 54922, Czech Republic

[11] Taichung Vet Gen Hosp, Dept Med Res, 1650 Sec 4,Taiwan Blvd, Taichung 407, Taiwan

[12] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, 702 Light Hall, Nashville, TN 37232 USA

[13] Katholieke Univ Leuven, Lab Lipid Biochem & Prot Interact LIPIT, Campus Gasthuisberg,Herestr Box 601, B-3000 Louvain, Belgium

[14] Louisiana State Univ, Coll Med, Hlth Sci Ctr, Dept Pharmacol & Expt Therapeut, 1901 Perdido Str, New Orleans, LA 70112 USA

[15] Univ Cambridge, Cambridge Univ Hosp, NIHR BRC Core Metabol & Lipid Lab, Level 4,Lab Block, Cambridge, England

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

英国医学研究理事会; 芬兰科学院; 英国生物技术与生命科学研究理事会;

关键词：

ADIPOSE-TISSUE; ALPHA-OXIDATION; DAIRY FAT; MILK; LIPOGENESIS; MARKER; LIPIDS; SERUM; MODEL; RISK;

D O I：

10.1038/srep44845

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent findings have shown an inverse association between circulating C15: 0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through combinations of both animal and human intervention studies, we comprehensively investigated all possible contributions of these fatty acids from the gut-microbiota, the diet, and novel endogenous biosynthesis. Investigations included an intestinal germ-free study and a C15:0/C17:0 diet dose response study. Endogenous production was assessed through: a stearic acid infusion, phytol supplementation, and a Hacl1(-/-) mouse model. Two human dietary intervention studies were used to translate the results. Finally, a study comparing baseline C15:0/C17:0 with the prognosis of glucose intolerance. We found that circulating C15:0/C17:0 levels were not influenced by the gut-microbiota. The dose response study showed C15:0 had a linear response, however C17:0 was not directly correlated. The phytol supplementation only decreased C17:0. Stearic acid infusion only increased C17:0. Hacl1(-/-) only decreased C17:0. The glucose intolerance study showed only C17:0

引用

页数：8

共 29 条

[1] Subcutaneous Adipose Tissue Remodeling during the Initial Phase of Weight Gain Induced by Overfeeding in Humans [J].

Alligier, M. ;

Meugnier, E. ;

Debard, C. ;

Lambert-Porcheron, S. ;

Chanseaume, E. ;

Sothier, M. ;

Loizon, E. ;

Hssain, A. Ait ;

Brozek, J. ;

Scoazec, J. -Y. ;

Morio, B. ;

Vidal, H. ;

Laville, M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (02) :E183-E192

[2] Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: Comparison with adipose tissue and plasma [J].

Baylin, A ;

Kim, MK ;

Donovan-Palmer, A ;

Siles, X ;

Dougherty, L ;

Tocco, P ;

Campos, H .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2005, 162 (04) :373-381

[3]

Benatar J. R., 2014, Nutrition Journal, V13

[4] Biomarkers for intake of dairy fat and dairy products [J].

Biong, Anne Sofie ;

Berstad, Paula ;

Pedersen, Jan I. .

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2006, 108 (10) :827-834

[5] Evaluation of the odd fatty acids 15:0 and 17:0 in serum and adipose tissue as markers of intake of milk and dairy fat [J].

Brevik, A ;

Veierod, MB ;

Drevon, CA ;

Andersen, LF .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2005, 59 (12) :1417-1422

[6] Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults [J].

Chiu, Sally ;

Williams, Paul T. ;

Dawson, Taylor ;

Bergman, Richard N. ;

Stefanovski, Darko ;

Watkins, Steven M. ;

Krauss, Ronald M. .

JOURNAL OF NUTRITION, 2014, 144 (11) :1753-1759

[7] Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding [J].

Coate, Katie C. ;

Kraft, Guillaume ;

Moore, Mary Courtney ;

Smith, Marta S. ;

Ramnanan, Christopher ;

Irimia, Jose M. ;

Roach, Peter J. ;

Farmer, Ben ;

Neal, Doss W. ;

Williams, Phil ;

Cherrington, Alan D. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2014, 307 (02) :E151-E160

[8]

Cornish-Bowden A., 2013, Fundamentals of Enzyme Kinetics

[9]

Croes K, 2000, J LIPID RES, V41, P629

[10] Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study [J].

Forouhi, Nita G. ;

Koulman, Albert ;

Sharp, Stephen J. ;

Imamura, Fumiaki ;

Kroger, Janine ;

Schulze, Matthias B. ;

Crowe, Francesca L. ;

Huerta, Jose Maria ;

Guevara, Marcela ;

Beulens, Joline W. J. ;

van Woudenbergh, Geertruida J. ;

Wang, Laura ;

Summerhill, Keith ;

Griffin, Julian L. ;

Feskens, Edith J. M. ;

Amiano, Pilar ;

Boeing, Heiner ;

Clavel-Chapelon, Francoise ;

Dartois, Laureen ;

Fagherazzi, Guy ;

Franks, Paul W. ;

Gonzalez, Carlos ;

Jakobsen, Marianne Uhre ;

Kaaks, Rudolf ;

Key, Timothy J. ;

Khaw, Kay-Tee ;

Kuhn, Tilman ;

Mattiello, Amalia ;

Nilsson, Peter M. ;

Overvad, Kim ;

Pala, Valeria ;

Palli, Domenico ;

Quiros, J. Ramon ;

Rolandsson, Olov ;

Roswall, Nina ;

Sacerdote, Carlotta ;

Sanchez, Mara-Jose ;

Slimani, Nadia ;

Spijkerman, Annemieke M. W. ;

Tjonneland, Anne ;

Tormo, Maria-Jose ;

Tumino, Rosario ;

van der A, Daphne L. ;

van der Schouw, Yvonne T. ;

Langenberg, Claudia ;

Riboli, Elio ;

Wareham, Nicholas J. .

LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (10) :810-818

← 1 2 3 →