Balancing cholesterol synthesis and absorption in the gastrointestinal tract

被引：100

作者：

Cohen, David E. ^{[1
,2
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

[2] Harvard Massachusetts Inst Technol, Div Hlth Sci & Technol, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2008年 / 2卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Bile; Fat; Intestine; Low-density lipoprotein;

D O I：

10.1016/j.jacl.2008.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cholesterol balance is achieved both by synthesis in the body and by absorption in the gastrointestinal tract. Cholesterol synthesis and absorption are also critical determinants of plasma low-density lipoprotein cholesterol (LDL-C) concentrations. In clinical practice, inhibitors of synthesis and inhibitors of absorption are both effective methods of lowering LDL-C concentrations and can be used in combination. This review rationalizes these mechanisms of LDL-C reductions by placing them in the context of cholesterol balance as it is determined by digestive lipid metabolism. (C) 2008 National Lipid Association. All rights reserved.

引用

页码：S1 / S3

页数：3

共 19 条

[1] Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption [J].