A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens

被引：24
作者：
Lodhi, Muhammad Arif
Hussain, Javid
Abbasi, Muhammad Athar
Jassbi, Amir Reza
Choudhary, Muhammad Iqbal
Ahmad, Viqar Uddin [1 ]
机构：
[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan
[2] Kohat Univ Sci & Technol, Kohat, Pakistan
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2006年 / 21卷 / 05期
关键词：
Euphorbia decipiens; Bacillus pasteurii urease; inhibition; kinetics; molecular docking;
D O I：
10.1080/14756360600586072
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. & Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 mu M.
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收藏
页码：531 / 535
页数：5
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