A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens

被引：25

作者：

Lodhi, Muhammad Arif

Hussain, Javid

Abbasi, Muhammad Athar

Jassbi, Amir Reza

Choudhary, Muhammad Iqbal

Ahmad, Viqar Uddin ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan

[2] Kohat Univ Sci & Technol, Kohat, Pakistan

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2006年 / 21卷 / 05期

关键词：

Euphorbia decipiens; Bacillus pasteurii urease; inhibition; kinetics; molecular docking;

D O I：

10.1080/14756360600586072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. & Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 mu M.

引用

页码：531 / 535

页数：5

共 20 条

[1]

Ahmad VU, 2003, CHEM PHARM BULL, V51, P719, DOI 10.1248/cpb.51.719

[2] Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles/thiadiazoles and triazoles [J].

Amtul, Z ;

Rasheed, M ;

Choudhary, MI ;

Rosanna, S ;

Khan, KM ;

Atta-ur-Rahman .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 319 (03) :1053-1063

[3] Chemistry and mechanism of urease inhibition [J].

Amtul, Z ;

Atta-ur-Rahman ;

Siddiqui, RA ;

Choudhary, MI .

CURRENT MEDICINAL CHEMISTRY, 2002, 9 (14) :1323-1348

[4] THE ROLE OF ANTIBIOTICS IN CAMPYLOBACTER-PYLORI ASSOCIATED PEPTIC-ULCER DISEASE [J].

BAYERDORFFER, E ;

OTTENJANN, R .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1988, 23 :93-100

[5] A WELL-BEHAVED ELECTROSTATIC POTENTIAL BASED METHOD USING CHARGE RESTRAINTS FOR DERIVING ATOMIC CHARGES - THE RESP MODEL [J].

BAYLY, CI ;

CIEPLAK, P ;

CORNELL, WD ;

KOLLMAN, PA .

JOURNAL OF PHYSICAL CHEMISTRY, 1993, 97 (40) :10269-10280

[6]

DAVIS PH, 1982, FLORA TURKEY E AEGEA, V7, P571

[7] ANTIDIARRHEIC ACTIVITY OF EUPHORBIA-HIRTA EXTRACT AND ISOLATION OF AN ACTIVE FLAVONOID CONSTITUENT [J].

GALVEZ, J ;

ZARZUELO, A ;

CRESPO, ME ;

LORENTE, MD ;

OCETE, MA ;

JIMENEZ, J .

PLANTA MEDICA, 1993, 59 (04) :333-336

[8] Macrocyclic diterpene polyesters of the jatrophane type from Euphorbia esula [J].

Hohmann, J ;

Vasas, A ;

Gunther, G ;

Methe, I ;

Evanics, F ;

Dombi, G ;

Jerkovich, G .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (04) :331-335

[9] VMD: Visual molecular dynamics [J].

Humphrey, W ;

Dalke, A ;

Schulten, K .

JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 1996, 14 (01) :33-38

[10] Biscoumarin: new class of urease inhibitors; economical synthesis and activity [J].

Khan, KM ;

Iqbal, S ;

Lodhi, MA ;

Maharvi, GM ;

Zia-Ullah ;

Choudhary, MI ;

Atta-ur-Rahman ;

Perveen, S .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (08) :1963-1968

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